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1. Nonparametric estimation of the cumulative incidences of competing risks under double truncation: (Publication); Registry data typically report incident cases within a certain calendar time interval. Such interval sampling induces double truncation on the incidence times, which may result in an observational bias. ...; Created on 21 January 2020
2. Traditional Processed Meat Products Re-designed Towards Inulin-rich Functional Foods Reduce Polyps in Two Colorectal Cancer Animal Models: (Publication); Inulin-rich foods exert a prebiotic effect, as this polysaccharide is able to enhance beneficial colon microbiota populations, giving rise to the in situ production of short-chain fatty acids (SCFAs) such ...; Created on 22 November 2019
3. Methylation Assessment for the Prediction of Malignancy in Mediastinal Adenopathies Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Patients with Lung Cancer: (Publication); The evaluation of mediastinal lymph nodes is critical for the correct staging of patients with lung cancer (LC). Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally ...; Created on 26 September 2019
4. Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: a Systematic Review and Meta-Analysis: (Publication); BACKGROUND & AIMS: Guidelines recommend individuals with familial colorectal cancer (FCC) to undergo colonoscopy surveillance instead of average-risk screening. However, these recommendations vary widely. ...; Created on 26 September 2019
5. Addition of a 161-SNP polygenic risk score to family history-based risk prediction: Impact on clinical management in non- BRCA1/2 breast cancer families: (Publication); Background The currently known breast cancer-associated single nucleotide polymorphisms (SNPs) are presently not used to guide clinical management. We explored whether a genetic test that incorporates ...; Created on 26 September 2019
6. The apparent genetic anticipation in PMS2-associated lynch syndrome families is explained by birth-cohort effect: (Publication); Background: PMS2-associated Lynch syndrome is characterized by a relatively low colorectal cancer penetrance compared with other Lynch syndromes. However, age at colorectal cancer diagnosis varies widely, ...; Created on 26 September 2019
7. Assessing a single SNP located at TERT/CLPTM1L multi-cancer risk region as a genetic modifier for risk of pancreatic cancer and melanoma in Dutch CDKN2A mutation carriers: (Publication); Carriers of pathogenic variants in CDKN2A have a 70% life-time risk of developing melanoma and 15–20% risk of developing pancreatic cancer (PC). In the Netherlands, a 19-bp deletion in exon 2 of CDKN2A ...; Created on 26 September 2019
8. An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome: (Publication); Purpose: Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members ...; Created on 26 September 2019
9. Complex decongestive therapy in the early stages of breast cancer-related lymphoedema: (Publication); Objectives To analyse the outcomes of Complex Decongestive Therapy (CDT) applied for the first time in patients with Breast Cancer-Related Lymphoedema (BCRL) stages 0-I. Material and methods A descriptive ...; Created on 24 September 2019
10. The apparent genetic anticipation effect in PMS2-associated Lynch syndrome families is explained by birth-cohort effect: (Publication); Background: PMS2-associated Lynch syndrome is characterized by a relatively low colorectal cancer penetrance compared with other Lynch syndromes. However, age at colorectal cancer diagnosis varies widely, ...; Created on 23 August 2019
11. Bootstrap-based testing approaches for the assessment of the diagnostic accuracy of biomarkers subject to a limit of detection: (Publication); Assessment of the diagnostic accuracy of biomarkers through receiver operating characteristic curve analysis frequently involves a limit of detection imposed by the laboratory analytical system precision. ...; Created on 09 October 2018
12. Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST-Q: (Publication); Aims and objectives: To analyse quality of life and satisfaction after immediate breast reconstruction due to cancer and its determining factors. Background: Studying breast reconstruction is important ...; Created on 08 October 2018
13. A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples o: (Publication); Background: Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive ...; Created on 22 May 2018
14. Improving stability of prediction models based on correlated omics data by using network approaches: (Publication); Building prediction models based on complex omics datasets such as transcriptomics, proteomics, metabolomics remains a challenge in bioinformatics and biostatistics. Regularized regression techniques are ...; Created on 22 May 2018
15. Performance of BRCA1/2 mutation prediction models in male breast cancer patients: (Publication); To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of ...; Created on 22 May 2018
16. Bootstrap-based procedures for inference in nonparametric receiver-operating characteristic curve regression analysis: (Publication); Prior to using a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is essential. The receiver-operating characteristic curve is the measure of accuracy most ...; Created on 22 May 2018
17. On the Combination of Omics Data for Prediction of Binary Outcomes: (Publication); Enrichment of predictive models with new biomolecular markers is an important task in high-dimensional omic applications. Increasingly, clinical studies include several sets of such omics markers available ...; Created on 10 October 2018
18. Quality of life and anxiety in women with breast cancer before and after treatment.: (Publication); Objectives: to determine the quality of life and anxiety in patients with breast cancer and the changes they experience after treatments. Method: prospective study. Breast cancer statistics (n=339, confidence=95%, ...; Created on 08 October 2018
19. Highly sensitive marker panel for guidance in Lung Cancer Rapid Diagnostic Units: (Publication); While evidence for lung cancer screening implementation in Europe is awaited, Rapid Diagnostic Units have been established in many hospitals to accelerate the early diagnosis of lung cancer. We seek to ...; Created on 18 September 2017
20. Cisplatin resistance in cell models: evaluation of metallomic and biological predictive biomarkers to address early therapy failure: (Publication); Cisplatin, one of the most extensively used metallodrugs in cancer treatment, presents the important drawback of patient resistance. This resistance is the consequence of different processes including ...; Created on 18 September 2017
21. Boostrap-based procedures for inference in nonparametric ROC regression analysis: (Publication); Before the use of a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is an essential step. The receiver operating characteristic (ROC) curve is the measure ...; Created on 10 December 2016
22. Nonparametric estimation of the survival function for ordered multivariate failure time data: A comparative study: (Publication); In longitudinal studies of disease, patients may experience several events through a follow-up period. In these studies, the sequentially ordered events are often of interest and lead to problems that ...; Created on 04 November 2016
23. Nonparametric estimation of conditional transition probabilities in a non-Markov illness-death model: (Publication); ... through a simulation study, leading to a comparison of two different estimators. The proposed methods are illustrated using a real colon cancer data set. Copyright Springer-Verlag Berlin Heidelberg 20 ...; Created on 04 September 2017
24. Nonparametric estimation of transition probabilities in the non-Markov illness-death model: a comparative study: (Publication); ... more efficient than the existing non-Markov estimators in most cases. An application to a clinical trial on colon cancer is included. Extensions to progressive processes beyond the three-state illness-death ...; Created on 01 September 2017
25. Predicting malignant and tuberculous pleural effusions through demographics and pleural fluid analysis of patients effusions: (Publication); IntroductionThe differential diagnosis of malignant and tuberculous pleural effusion is frequently difficult. ObjectivesThe aim of our study is to determine the discrimination value of demographic ...; Created on 01 September 2017
26. Bandwidth selection for the estimation of transition probabilities in the location-scale progressive three-state model: (Publication); Times between consecutive events are often of interest in medical studies. Usually the events represent different states of the disease process and are modeled using multi-state models. This paper introduces ...; Created on 04 September 2017
27. A Simulation Study on the Impact of Strong Dependence in High-Dimensional Multiple-Testing I: The Case without Effects: (Publication); When working with high-dimensional biological data the so-called multiple hypothesis testing problem emerges. That is, when many separate tests are performed, several will be significant by chance provoking ...; Created on 10 January 2019
28. A semiparametric estimator of survival for doubly truncated data: (Publication); Doubly truncated data are often encountered in the analysis of survival times, when the sample reduces to those individuals with terminating event falling on a given observational window. In this paper ...; Created on 08 September 2017
29. Assessing continuous bivariate effects among different groups through nonparametric regression models. An application to breast cancer detection: (Publication); Created on 12 September 2017