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1. Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: a Systematic Review and Meta-Analysis: (Publication); BACKGROUND & AIMS: Guidelines recommend individuals with familial colorectal cancer (FCC) to undergo colonoscopy surveillance instead of average-risk screening. However, these recommendations vary widely. ...; Created on 26 September 2019
2. Addition of a 161-SNP polygenic risk score to family history-based risk prediction: Impact on clinical management in non- BRCA1/2 breast cancer families: (Publication); Background The currently known breast cancer-associated single nucleotide polymorphisms (SNPs) are presently not used to guide clinical management. We explored whether a genetic test that incorporates ...; Created on 26 September 2019
3. Assessing a single SNP located at TERT/CLPTM1L multi-cancer risk region as a genetic modifier for risk of pancreatic cancer and melanoma in Dutch CDKN2A mutation carriers: (Publication); Carriers of pathogenic variants in CDKN2A have a 70% life-time risk of developing melanoma and 15–20% risk of developing pancreatic cancer (PC). In the Netherlands, a 19-bp deletion in exon 2 of CDKN2A ...; Created on 26 September 2019
4. An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome: (Publication); Purpose: Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members ...; Created on 26 September 2019
5. Gestational Weight Gain and Offspring Bone Mass: Different Associations in Healthy Weight Versus Overweight Women: (Publication); Weight management strategies during pregnancy reduce child cardiometabolic risk. However, because maternal weight has an overall positive correlation with offspring bone mass, pregnancy weight management ...; Created on 25 September 2019
6. Five-year reintervention after endovascular abdominal aortic aneurysm repair in the Vascular Quality Initiative: (Publication); Objective: Patients who undergo endovascular abdominal aortic aneurysm repair (EVR) remain at risk for reintervention and rupture. We sought to define the 5-year rate of reintervention and rupture after ...; Created on 25 September 2019
7. The importance of the mediastinal triangle in traumatic lesions of the aorta: (Publication); Background: Trauma-induced aortic injuries continue to be an important factor in morbimortality in patients with blunt trauma. Objectives: To determine the characteristics of aortic lesions in patients ...; Created on 24 September 2019
8. Treatment with tenofovir alafenamide fumarate worsens the lipid profile of HIV-infected patients versus treatment with tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and ...: (Publication); ... were prescribed (11.9%) in the EVG/c/FTC/TAF group. The number of cardiovascular risk factors (OR 1.66 [95% CI 1.01-2.72]; P = 0.043) was recognised as an independent predictor of lipid-lowering prescription ...; Created on 24 September 2019
9. Erectile dysfunction in patients with arterial hypertension. Cardiovascular risk and impact on their quality of life: (Publication); Objectives: Estimate the frequency of erectile dysfunction in patients with essential hypertension and associated variables, degree of control, cardiovascular risk and the impact on quality of life. Material ...; Created on 24 September 2019
10. Late HIV Diagnosis but Earlier Antiretroviral Treatment Initiation in Northwest Spain: Impact of Current Treatment Guidelines: (Publication); Background: Current HIV treatment guidelines recommend antiretroviral treatment (ART) initiation for all HIV-infected individuals regardless of CD4 count. This study evaluates the immunological and virological ...; Created on 24 September 2019
11. Concordance between the Different Cardiovascular Risk Scores in People with Rheumatoid Arthritis and Psoriasis Arthritis: (Publication); ... most prevalent risk factors were overweight and obesity, followed by smoking and hypertension. The prevalence of patients with moderate/high cardiovascular risk varies according to the score used, the ...; Created on 24 September 2019
12. Incidence rate and clinicopathological features of 62 atypical fibroxanthomas in a North-Western Spanish population: (Publication); Background/Objectives: Atypical fibroxanthoma (AFX) is a mesenchymal neoplasm of unknown incidence. It has been determined that AFX is a tumour with low aggressiveness as long as it is properly diagnosed. ...; Created on 24 September 2019
13. Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait: (Publication); Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is challenging. There is debate concerning the survival ...; Created on 23 August 2019
14. Systematic review with meta‐analysis: risk factors for recurrent primary sclerosing cholangitis after liver transplantation ...: (Publication); ... define risk factors for rPSC. Methods We searched Pubmed, Embase, Web of Science, and Cochrane library for articles published until March 2018. Studies addressing risk factors for developing rPSC were ...; Created on 23 August 2019
15. A comparative analysis of long-term mortality after carotid endarterectomy and carotid stenting: (Publication); Background The value of carotid intervention is predicated on long-term survival for patients to derive a stroke prevention benefit. Randomized trials report no significant difference in survival after ...; Created on 22 August 2019
16. Circulating microRNAs in suspected stable coronary artery disease: A coronary computed tomography angiography study: (Publication); ... Detector (CHAID) prediction models. Results After comprehensive adjustment including cardiovascular risk factors, medication use, confounding factors and protein‐based biomarkers (hs‐TnT and hs‐CRP), ...; Created on 22 August 2019
17. Plasma microRNA Profiling Reveals Novel Biomarkers of Epicardial Adipose Tissue: A Multidetector Computed Tomography Study: (Publication); Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and a target for therapy. Here, we evaluated for the first time the plasma microRNA (miRNA) profile as ...; Created on 22 August 2019
18. Adverse Events After Atherectomy: Analyzing Long‐Term Outcomes of Endovascular Lower Extremity Revascularization Techniques: (Publication); Background The long-term effectiveness of atherectomy treatment for peripheral arterial disease is unknown. We studied 5-year clinical outcomes by endovascular treatment type among patients with peripheral ...; Created on 22 August 2019
19. Long-term Reintervention After Endovascular Abdominal Aortic Aneurysm Repair: (Publication); ... reintervention: operative time ≥3.0 hours, aneurysm diameter ≥6.0 cm, an iliac artery aneurysm ≥2.0 cm, emergency surgery, and a history of prior aortic surgery. Patients with no risk factors had a 3-year ...; Created on 22 August 2019
20. External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study: (Publication); The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the ...; Created on 22 August 2019
21. Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma: (Publication); The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there ...; Created on 22 August 2019
22. Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma: (Publication); Background Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous ...; Created on 22 August 2019
23. Serum phosphate optimal timing and range associated with patients survival in haemodialysis: the COSMOS study: (Publication); Background Serum phosphate is a key parameter in the management of chronic kidney disease-mineral and bone disorder (CKD-MBD). The timing of phosphate measurement is not standardized in the current guidelines. ...; Created on 10 October 2018
24. Spatial heterogeneity in Spain for senior travel behavior: (Publication); Travel patterns are becoming more differentiated, influenced by new variables resulting from changes in lifestyle. The relevance of the senior segment for this industry, with the continuous aging population ...; Created on 08 October 2018
25. Liberal red blood cell transfusions impair quality of life after cardiac surgery: (Publication); ... of life after the surgical intervention was added to the HRQoL questionnaire. Risk factors related to impaired quality of life were identified using univariate comparisons and multivariate regression techniques. RESULTS: ...; Created on 01 October 2018
26. Bayesian nonparametric inference for the covariate-adjusted ROC curve: (Publication); ... and applied to an endocrine study where the main goal is to assess the accuracy of the body mass index, adjusted for age and gender, for predicting clusters of cardiovascular disease risk factors. Th ...; Created on 10 October 2018
27. Erectile dysfunction in patients with arterial hypertension. Cardiovascular risk and impact on their quality of life: (Publication); OBJECTIVES: Estimate the frequency of erectile dysfunction in patients with essential hypertension and associated variables, degree of control, cardiovascular risk and the impact on quality of life. MATERIAL ...; Created on 08 October 2018
28. Predictive factors of satisfaction and quality of life after immediate breast reconstruction using the BREAST-Q: (Publication); Aims and objectives: To analyse quality of life and satisfaction after immediate breast reconstruction due to cancer and its determining factors. Background: Studying breast reconstruction is important ...; Created on 08 October 2018
29. Levels of anti-CMV antibodies are modulated by the frequency and intensity of virus reactivations in kidney transplant patients: (Publication); Anti-CMV (cytomegalovirus) antibody titers are related to immune alterations and increased risk of mortality. To test whether they represent a marker of infection history, we analyzed the effect of viral ...; Created on 22 May 2018
30. Clinical experience with the integrase inhibitors Dolutegravir and Elvitegravir in HIV-infected patients: Efficacy, safety and tolerance: (Publication); ... risk factors for treatment discontinuations in two different multivariate analyses. A high percentage of AE discontinuations not previously described in clinical trials has been observed, especially with ...; Created on 19 September 2017
31. Sentinel lymph node biopsy plus wide local excision vs. wide location excision alone for primary cutaneous melanoma: a systematic review and meta‐analysis: (Publication); Background: Sentinel lymph node biopsy and wide local excision of the primary melanoma (SLNB) is now a standard staging procedure for patients with melanomas 1 mm or more in thickness, but its therapeutic ...; Created on 18 September 2017
32. The adverse prognostic effect of tumor budding on the evolution of cutaneous head and neck squamous cell carcinoma.: (Publication); Background: Tumor budding is a readily detectable histopathologic feature that has been recognized as an adverse prognostic factor in several human cancers. Objective: We sought to assess the correlation ...; Created on 18 September 2017
33. Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck.: (Publication); Background: Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 ...; Created on 18 September 2017
34. Incidence of cardiovascular events and associated risk factors in kidney transplant patients: a competing risks survival analysis ...: (Publication); Background: The high prevalence of cardiovascular risk factors among the renal transplant population accounts for increased mortality. The aim of this study is to determine the incidence of cardiovascular ...; Created on 18 September 2017
35. Semiparametric estimation of risk-return relationships: (Publication); This article proposes semiparametric generalized least-squares estimation of parametric restrictions between the conditional mean and the conditional variance of excess returns given a set of parametric ...; Created on 01 September 2017
36. The interdialytic period for blood collection influences serum phosphorus and the risk of mortality in the cosmos study: (Publication); Phosphorus (P), calcium (Ca) and PTH are the main serum biochemical parameters of bone and mineral metabolism used for the current management of Chronic Kidney Disease-Mineral and Bone Disorders (CKD-MBD). ...; Created on 18 September 2017
37. Kaplan-Meier estimator in competing risk contexts: (Publication); Survival analysis has become in a common procedure in biomedical researches. Conventionally, the well-known nonparametric Kaplan-Meier (KM) estimator is used in order to approximate the real survivor curve. ...; Created on 18 September 2017
38. Risk factors for tuberculosis in inflammatory bowel disease: anti-tumor necrosis factor and hospitalization ...: (Publication); Aims: To determine risk factors for active tuberculosis in patients with inflammatory bowel diseases. Methods: Retrospective, case-control study at 4 referral hospitals in Spain. Cases developed tuberculosis ...; Created on 18 September 2017
39. High levels of atrial natriuretic peptide and copeptin and mortality risk: (Publication); Objective: To determine whether high levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin (PCT) plasma concentrations are associated with increased mortality risk. Methods: ...; Created on 18 September 2017
40. No change in Interictal PACAP levels in peripheral blood in women with chronic Migraine: (Publication); ... variables such as age, CM duration, the presence of aura, analgesic overuse, depression, fibromyalgia, vascular risk factors, history of triptan consumption or kind of preventative treatment did not significantly ...; Created on 18 September 2017
41. Surveillance after cardiac arrest in patients with Brugada syndrome without an implantable defibrillator: An alarm effect of the previous syncope: (Publication); ... p = 0.442), prior cardiomyopathy (0%), administration of cardiovascular treatments (anti-hypertensive and lipid-lowering drugs; 20% vs. 14.8%; p = 0.653) or conventional cardiovascular risk factors. Environmental ...; Created on 07 November 2016
42. Prognostic assessment in COPD without lung function: The B-AE-D indices: (Publication); Several composite markers have been proposed for risk assessment in chronic obstructive pulmonary disease (COPD). However, choice of parameters and score complexity restrict clinical applicability. Our ...; Created on 07 November 2016
43. Effectiveness of azacitidine for the treatment of higher-risk myelodysplastic syndromes in daily practice: The authors' reply: (Publication); Created on 04 November 2016
44. Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology ...: (Publication); Objectives: To identify patterns (clusters) of damage manifestations within a large cohort of SLE patients and evaluate the potential association of these clusters with a higher risk of mortality. Methods: ...; Created on 24 October 2016
45. Expanded renal transplantation: A competing risk model approach: (Publication); Multi-state models (MSMs) are useful to analyze survival data when, besides the event of main interest, one or more intermediate states of the individual are identified. These models take the several existing ...; Created on 01 September 2017
46. Severe acute kidney injury in critically ill children: Epidemiology and prognostic factors: (Publication); ... children from 7 days to 16 years old who were admitted to a PICU. A univariate and multivariate logistic regression analysis of the risk factors for mortality and renal replacement therapy at PICU discharge ...; Created on 01 September 2017
47. Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2007 and 2011 staging systems: a pooled analysis of individual patient data: (Publication); Background There is no universal consensus on the best staging system for chronic obstructive pulmonary disease (COPD). Although documents (eg, the Global Initiative for Chronic Obstructive Lung Disease ...; Created on 01 September 2017
48. Merkel cell carcinoma and Merkel cell polyomavirus: a systematic review and meta-analysis: (Publication); Several observational studies have assessed the correlation between Merkel cell carcinoma and Merkel cell polyomavirus with variable results. The objective of this systematic review was to determine whether ...; Created on 01 September 2017
49. Clinical significance of ANOCTAMIN-1 gene at 11q13 in the development and progression of head and neq aquamous cell carcinomas: (Publication); This study investigates the clinical significance of Anoctamin-1 gene mapping at 11q13 amplicon in both the development and progression of head and neck squamous cell carcinomas (HNSCC). ANO1 protein expression ...; Created on 01 September 2017
50. Improvement of mineral and bone metabolism markers in associated with better survival in hemodialysis patients: the COSMOS study: (Publication); Abnormalities in serum phosphorus, calcium and parathyroid hormone (PTH) have been associated with poor survival in haemodialysis patients. This COSMOS (Current management Of Secondary hyperparathyroidism: ...; Created on 01 September 2017