Facultade de Fisioterapia

Bootstrap-based procedures for inference in nonparametric receiver-operating characteristic curve regression analysis

Rodríguez Álvarez, María Xosé; Roca Pardiñas, Javier; Cadarso-Suarez, Carmen; Tahoces, Pablo G.
Abstract:
Prior to using a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is essential. The receiver-operating characteristic curve is the measure of accuracy most widely used for continuous diagnostic tests. However, the possible impact of extra information about the patient (or even the environment) on diagnostic accuracy also needs to be assessed. In this paper, we focus on an estimator for the covariate-specific receiver-operating characteristic curve based on direct regression modelling and nonparametric smoothing techniques. This approach defines the class of generalised additive models for the receiver-operating characteristic curve. The main aim of the paper is to offer new inferential procedures for testing the effect of covariates on the conditional receiver-operating characteristic curve within the above-mentioned class. Specifically, two different bootstrap-based tests are suggested to check (a) the possible effect of continuous covariates on the receiver-operating characteristic curve and (b) the presence of factor-by-curve interaction terms. The validity of the proposed bootstrap-based procedures is supported by simulations. To facilitate the application of these new procedures in practice, an R-package, known as npROCRegression, is provided and briefly described. Finally, data derived from a computer-aided diagnostic system for the automatic detection of tumour masses in breast cancer is analysed.
Year:
2018
Type of Publication:
Article
Keywords:
Receiver-operating characteristic curve; generalised additive models; bootstrap; computer-aided diagnosis
Journal:
Statistical Methods in Medical Research
Volume:
27
Number:
3
Pages:
740-764
Month:
March
Note:
Q1 17/123 h-index 2.284 (JCR2017)
DOI:
10.1177/0962280217742542
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