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1. The role of the p-value in the multitesting problem: (Publication); Modern science frequently involves the analysis of large amount of quantitative information and the simultaneous testing of thousands or even hundreds of thousands null hypotheses. In this context, sometimes, ...; Created on 22 November 2019
2. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 25 September 2019
3. On the optimism correction of the area under the receiver operating characteristic curve in logistic prediction models: (Publication); When the same data are used to fit a model and estimate its predictive performance, this estimate may be optimistic, and its correction is required. The aim of this work is to compare the behaviour of ...; Created on 25 September 2019
4. The importance of the mediastinal triangle in traumatic lesions of the aorta: (Publication); Background: Trauma-induced aortic injuries continue to be an important factor in morbimortality in patients with blunt trauma. Objectives: To determine the characteristics of aortic lesions in patients ...; Created on 24 September 2019
5. Cultural differences, language attitudes and tourist satisfaction: a study in the Barcelona hotel sector: (Publication); In most service activities, customer satisfaction depends largely on the direct interaction with service providers. In the case of tourism, this interaction often occurs between people from different countries ...; Created on 24 September 2019
6. A method for determining groups in multiple survival curves: (Publication); Survival analysis includes a wide variety of methods for analyzing time‐to‐event data. One basic but important goal in survival analysis is the comparison of survival curves between groups. Several nonparametric ...; Created on 23 August 2019
7. Testing critical points of nonparametric regression curves: application to the management of stalked barnacles: (Publication); Several aquatic living resources are overexploited. An example of this is a barnacle fishery, which is a commercial species that commands high prices in the market. We feel that not enough is known about ...; Created on 23 August 2019
8. Circulating microRNAs in suspected stable coronary artery disease: A coronary computed tomography angiography study: (Publication); Objectives To explore the diagnostic performance of circulating microRNAs (miRNAs) as biomarkers in patients with suspected stable coronary artery disease (CAD). Methods Plasma samples were collected ...; Created on 22 August 2019
9. Plasma microRNA Profiling Reveals Novel Biomarkers of Epicardial Adipose Tissue: A Multidetector Computed Tomography Study: (Publication); Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and a target for therapy. Here, we evaluated for the first time the plasma microRNA (miRNA) profile as ...; Created on 22 August 2019
10. Improving the biomarker diagnostic capacity via functional transformations: (Publication); The use of the area under the receiver-operating characteristic, ROC, curve (AUC) as an index of diagnostic accuracy is overwhelming in fields such as biomedical science and machine learning. It seems ...; Created on 22 August 2019
11. External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study: (Publication); The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the ...; Created on 22 August 2019
12. The Youden Index in the Generalized Receiver Operating Characteristic Curve Context: (Publication); The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker ...; Created on 22 August 2019
13. Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma: (Publication); The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there ...; Created on 22 August 2019
14. Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma: (Publication); Background Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous ...; Created on 22 August 2019
15. A new semantic-based feature selection method for spam filtering: (Publication); The Internet emerged as a powerful infrastructure for the worldwide communication and interaction of people. Some unethical uses of this technology (for instance spam or viruses) generated challenges in ...; Created on 15 January 2019
16. Bootstrap-based testing approaches for the assessment of the diagnostic accuracy of biomarkers subject to a limit of detection: (Publication); Assessment of the diagnostic accuracy of biomarkers through receiver operating characteristic curve analysis frequently involves a limit of detection imposed by the laboratory analytical system precision. ...; Created on 09 October 2018
17. Diagnostic accuracy of STOP-Bang questionnaire on moderate sleep apnoea in primary care: (Publication); OBJECTIVE: We aimed to compare the diagnostic utility of the STOP-Bang questionnaire for moderate apnoea against the gold standard (type I polysomnography) in a primary care setting. METHOD: Study of ...; Created on 02 October 2018
18. Parametric estimates for the receiver operating characteristic curve generalization for non-monotone relationships: (Publication); Diagnostic procedures are based on establishing certain conditions and then checking if those conditions are satisfied by a given individual. When the diagnostic procedure is based on a continuous marker, ...; Created on 22 May 2018
19. Injury prediction in aerobic gymnastics based on anthropometric variables: (Publication); Objective Use logistic regression to determine a mathematical model which is able to predict injuries in aerobic gymnastics (AG) athletes, according to certain anthropometric characteristics. Subjects ...; Created on 11 October 2018
20. Bayesian nonparametric inference for the covariate-adjusted ROC curve: (Publication); Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between ...; Created on 10 October 2018
21. nsROC: An R package for non-standard ROC curve analysis: (Publication); The receiver operating characteristic (ROC) curve is a graphical method which has become standard in the analysis of diagnostic markers, that is, in the study of the classiﬁcation ability of a numerical ...; Created on 10 October 2018
22. A Diagnostic Test Approach for Multitesting Problems: (Publication); In the last decades, multiple-testing problems have received much attention. Many different methods have been proposed in order to deal with this relevant issue. Most of them are focused on controlling ...; Created on 10 October 2018
23. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 02 October 2018
24. Efficient nonparametric confidence bands for receiver operating-characteristic curves: (Publication); Receiver operating-characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous (bio)markers. In spite of the existence of a huge number of ...; Created on 01 October 2018
25. Performance of BRCA1/2 mutation prediction models in male breast cancer patients: (Publication); To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of ...; Created on 22 May 2018
26. Bootstrap-based procedures for inference in nonparametric receiver-operating characteristic curve regression analysis: (Publication); ... receiver-operating characteristic curve and (b) the presence of factor-by-curve interaction terms. The validity of the proposed bootstrap-based procedures is supported by simulations. To facilitate the ...; Created on 22 May 2018
27. Levels of anti-CMV antibodies are modulated by the frequency and intensity of virus reactivations in kidney transplant patients: (Publication); Anti-CMV (cytomegalovirus) antibody titers are related to immune alterations and increased risk of mortality. To test whether they represent a marker of infection history, we analyzed the effect of viral ...; Created on 22 May 2018
28. Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease: (Publication); Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive ...; Created on 22 May 2018
29. Smooth time-dependent receiver operating characteristic curve estimators: (Publication); The receiver operating characteristic curve is a popular graphical method often used to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent variable, ...; Created on 22 May 2018
30. A non-iterative estimator for interval sampling and doubly truncated data: (Publication); This book is a tribute to Professor Pedro Gil, who created the Department of Statistics, OR and TM at the University of Oviedo, and a former President of the Spanish Society of Statistics and OR (SEIO). ...; Created on 16 March 2018
31. Geographically Weighted Principal Components Analysis to assess diffuse pollution sources of soil heavy metal: Application to rough mountain areas in Northwest Spain.: (Publication); Heavy metal pollution can result in the degradation of the soil, air and water bodies' quality affecting the health of all living organism. We analyze the spatial distribution of the concentrations of ...; Created on 24 January 2018
32. A new approach to categorising continuous variables in prediction models: Proposal and validation: (Publication); When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded ...; Created on 22 May 2018
33. Wavelet estimation of density for censored data with censoring indicator missing at random: (Publication); In this paper, we define the nonlinear wavelet estimator of density for the right censoring model with the censoring indicator missing at random (MAR), and develop its asymptotic expression for mean integrated ...; Created on 22 May 2018
34. Highly sensitive marker panel for guidance in Lung Cancer Rapid Diagnostic Units: (Publication); While evidence for lung cancer screening implementation in Europe is awaited, Rapid Diagnostic Units have been established in many hospitals to accelerate the early diagnosis of lung cancer. We seek to ...; Created on 18 September 2017
35. Comparing some production functions for inpatient health services in selected public hospitals in Spain: (Publication); To investigate the adequacy of the widely used Cobb-Douglas and transcendental logarithmic (translog) models of the production functions of hospital inpatient services, the authors fitted these and additive ...; Created on 18 September 2017
36. npregfast: an R package for nonparametric estimation and inference in life sciences: (Publication); We present the R npregfast package via some applications involved with the study of living organisms. The package implements nonparametric estimation procedures in regression models with or without factor-by-curve ...; Created on 18 September 2017
37. Fully non-parametric receiver operating characteristic curve estimation for random-effects meta-analysis: (Publication); Meta-analyses, broadly defined as the quantitative review and synthesis of the results of related but independent comparable studies, allow to know the state of the art of one considered topic. Since the ...; Created on 18 September 2017
38. Receiver operating characteristic curve generalization for non-monotone relationships: (Publication); The receiver operating characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous markers. It represents in a plot true-positive rates against ...; Created on 18 September 2017
39. The adverse prognostic effect of tumor budding on the evolution of cutaneous head and neck squamous cell carcinoma.: (Publication); Background: Tumor budding is a readily detectable histopathologic feature that has been recognized as an adverse prognostic factor in several human cancers. Objective: We sought to assess the correlation ...; Created on 18 September 2017
40. Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck.: (Publication); Background: Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 ...; Created on 18 September 2017
41. Effects of situational variables on offensive performance indicators in elite water polo: (Publication); The aim of this study was to assess the effect of quality of opposition, starting quarter score and match location on offensive performance indicators in the First Spanish Professional Water Polo League. ...; Created on 18 September 2017
42. Non-parametric ROC summary statistics: (Publication); Receiver operating characteristic (ROC) curves are useful statistical tools for medi- cal diagnostic testing. It has been proved its capability to assess diagnostic marker’s ability to distinguish between ...; Created on 08 September 2017
43. Performance Assessment in Water Polo Using Compositional Data Analysis: (Publication); The aim of the present study was to identify groups of offensive performance indicators which best discriminated between a match score (favourable, balanced or unfavourable) in water polo. The sample comprised ...; Created on 18 September 2017
44. Deformation analysis in tunnels through curve clustering: (Publication); Deformations in tunnels and galleries due to confinement pressures can occur continuously but also at discrete time intervals. We propose a methodology to detect discrete significant deformations in tunnels ...; Created on 18 September 2017
45. Kaplan-Meier estimator in competing risk contexts: (Publication); Survival analysis has become in a common procedure in biomedical researches. Conventionally, the well-known nonparametric Kaplan-Meier (KM) estimator is used in order to approximate the real survivor curve. ...; Created on 18 September 2017
46. Risk factors for tuberculosis in inflammatory bowel disease: anti-tumor necrosis factor and hospitalization: (Publication); Aims: To determine risk factors for active tuberculosis in patients with inflammatory bowel diseases. Methods: Retrospective, case-control study at 4 referral hospitals in Spain. Cases developed tuberculosis ...; Created on 18 September 2017
47. High levels of atrial natriuretic peptide and copeptin and mortality risk: (Publication); Objective: To determine whether high levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin (PCT) plasma concentrations are associated with increased mortality risk. Methods: ...; Created on 18 September 2017
48. Revisiting environmental Kuznets curves through the energy price lens: (Publication); The goal of this paper is to provide new insights to elucidate the inconclusive results from the Environmental Kuznets Curve (EKC) empirical literature. For the first time in empirical literature, an econometric ...; Created on 08 September 2017
49. Boostrap-based procedures for inference in nonparametric ROC regression analysis: (Publication); ... Speciﬁcally, two diﬀerent bootstrap-based tests are suggested to check (a) the possible eﬀect of continuous covariates on the ROC curve; and (b) the presence of factor-by-curve interaction terms. The validity ...; Created on 10 December 2016
50. Surveillance after cardiac arrest in patients with Brugada syndrome without an implantable defibrillator: An alarm effect of the previous syncope: (Publication); Background: Debate regarding the prognosis of asymptomatic patients with Brugada syndrome (BrS) is possibly affected by the selection bias of survivors of sudden cardiac arrest (SCA). We aimed to determine ...; Created on 07 November 2016