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1. The role of the p-value in the multitesting problem: (Publication); Modern science frequently involves the analysis of large amount of quantitative information and the simultaneous testing of thousands or even hundreds of thousands null hypotheses. In this context, sometimes, ...; Created on 22 November 2019
2. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 25 September 2019
3. On the optimism correction of the area under the receiver operating characteristic curve in logistic prediction models: (Publication); When the same data are used to fit a model and estimate its predictive performance, this estimate may be optimistic, and its correction is required. The aim of this work is to compare the behaviour of ...; Created on 25 September 2019
4. Post-stroke shoulder pain subtypes classifying criteria: towards a more specific assessment and improved physical therapeutic care: (Publication); Background: Post-stroke Shoulder Pain (PSSP) is a common stroke-related syndrome that prolongs hospitalization and diminishes quality of life. PSSP studies were unsuccessful in clarifying pathophysiological ...; Created on 24 September 2019
5. Incidence rate and clinicopathological features of 62 atypical fibroxanthomas in a North-Western Spanish population: (Publication); Background/Objectives: Atypical fibroxanthoma (AFX) is a mesenchymal neoplasm of unknown incidence. It has been determined that AFX is a tumour with low aggressiveness as long as it is properly diagnosed. ...; Created on 24 September 2019
6. A method for determining groups in multiple survival curves: (Publication); Survival analysis includes a wide variety of methods for analyzing time‐to‐event data. One basic but important goal in survival analysis is the comparison of survival curves between groups. Several nonparametric ...; Created on 23 August 2019
7. Testing critical points of nonparametric regression curves: application to the management of stalked barnacles: (Publication); Several aquatic living resources are overexploited. An example of this is a barnacle fishery, which is a commercial species that commands high prices in the market. We feel that not enough is known about ...; Created on 23 August 2019
8. Circulating microRNAs in suspected stable coronary artery disease: A coronary computed tomography angiography study: (Publication); ... were used to analyse the associations between biomarkers and indexes. Discrimination was evaluated using the area under the ROC curve (AUC). Decision trees were generated using chi‐squared Automatic Interaction ...; Created on 22 August 2019
9. Plasma microRNA Profiling Reveals Novel Biomarkers of Epicardial Adipose Tissue: A Multidetector Computed Tomography Study: (Publication); Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and a target for therapy. Here, we evaluated for the first time the plasma microRNA (miRNA) profile as ...; Created on 22 August 2019
10. Improving the biomarker diagnostic capacity via functional transformations: (Publication); The use of the area under the receiver-operating characteristic, ROC, curve (AUC) as an index of diagnostic accuracy is overwhelming in fields such as biomedical science and machine learning. It seems ...; Created on 22 August 2019
11. External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study: (Publication); The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the ...; Created on 22 August 2019
12. The Youden Index in the Generalized Receiver Operating Characteristic Curve Context: (Publication); The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker ...; Created on 22 August 2019
13. Bootstrap-based testing approaches for the assessment of the diagnostic accuracy of biomarkers subject to a limit of detection: (Publication); Assessment of the diagnostic accuracy of biomarkers through receiver operating characteristic curve analysis frequently involves a limit of detection imposed by the laboratory analytical system precision. ...; Created on 09 October 2018
14. Spatial heterogeneity in Spain for senior travel behavior: (Publication); Travel patterns are becoming more differentiated, influenced by new variables resulting from changes in lifestyle. The relevance of the senior segment for this industry, with the continuous aging population ...; Created on 08 October 2018
15. Diagnostic accuracy of STOP-Bang questionnaire on moderate sleep apnoea in primary care: (Publication); OBJECTIVE: We aimed to compare the diagnostic utility of the STOP-Bang questionnaire for moderate apnoea against the gold standard (type I polysomnography) in a primary care setting. METHOD: Study of ...; Created on 02 October 2018
16. Parametric estimates for the receiver operating characteristic curve generalization for non-monotone relationships: (Publication); Diagnostic procedures are based on establishing certain conditions and then checking if those conditions are satisfied by a given individual. When the diagnostic procedure is based on a continuous marker, ...; Created on 22 May 2018
17. Bayesian nonparametric inference for the covariate-adjusted ROC curve: (Publication); Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between ...; Created on 10 October 2018
18. nsROC: An R package for non-standard ROC curve analysis: (Publication); The receiver operating characteristic (ROC) curve is a graphical method which has become standard in the analysis of diagnostic markers, that is, in the study of the classiﬁcation ability of a numerical ...; Created on 10 October 2018
19. A Diagnostic Test Approach for Multitesting Problems: (Publication); In the last decades, multiple-testing problems have received much attention. Many different methods have been proposed in order to deal with this relevant issue. Most of them are focused on controlling ...; Created on 10 October 2018
20. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 02 October 2018
21. Efficient nonparametric confidence bands for receiver operating-characteristic curves: (Publication); Receiver operating-characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous (bio)markers. In spite of the existence of a huge number of ...; Created on 01 October 2018
22. Functional differences between shipbuilding workers with an asbestos exposure in the northwest of the iberian peninsule (Diferencias funcionales entre trabajadores de astilleros expuestos al amianto del ...: (Publication); Introduction. One of the population with higher exposure to asbestos is composed by shipyard´s workers. Different risks have been theorized according to the type of naval construction, relating higher ...; Created on 22 May 2018
23. Performance of BRCA1/2 mutation prediction models in male breast cancer patients: (Publication); To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of ...; Created on 22 May 2018
24. Bootstrap-based procedures for inference in nonparametric receiver-operating characteristic curve regression analysis: (Publication); Prior to using a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is essential. The receiver-operating characteristic curve is the measure of accuracy most ...; Created on 22 May 2018
25. Levels of anti-CMV antibodies are modulated by the frequency and intensity of virus reactivations in kidney transplant patients: (Publication); Anti-CMV (cytomegalovirus) antibody titers are related to immune alterations and increased risk of mortality. To test whether they represent a marker of infection history, we analyzed the effect of viral ...; Created on 22 May 2018
26. Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease: (Publication); Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive ...; Created on 22 May 2018
27. Smooth time-dependent receiver operating characteristic curve estimators: (Publication); The receiver operating characteristic curve is a popular graphical method often used to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent variable, ...; Created on 22 May 2018
28. A new approach to categorising continuous variables in prediction models: Proposal and validation: (Publication); When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded ...; Created on 22 May 2018
29. Wavelet estimation of density for censored data with censoring indicator missing at random: (Publication); In this paper, we define the nonlinear wavelet estimator of density for the right censoring model with the censoring indicator missing at random (MAR), and develop its asymptotic expression for mean integrated ...; Created on 22 May 2018
30. npregfast: an R package for nonparametric estimation and inference in life sciences: (Publication); We present the R npregfast package via some applications involved with the study of living organisms. The package implements nonparametric estimation procedures in regression models with or without factor-by-curve ...; Created on 18 September 2017
31. Intestinal microbiota and weight-gain in preterm neonates: (Publication); The involvement of the gut microbiota on weight-gain and its relationship with childhood undernutrition and growth has been reported. Thus, the gut microbiota constitutes a potential therapeutic target ...; Created on 18 September 2017
32. Fully non-parametric receiver operating characteristic curve estimation for random-effects meta-analysis: (Publication); Meta-analyses, broadly defined as the quantitative review and synthesis of the results of related but independent comparable studies, allow to know the state of the art of one considered topic. Since the ...; Created on 18 September 2017
33. Receiver operating characteristic curve generalization for non-monotone relationships: (Publication); The receiver operating characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous markers. It represents in a plot true-positive rates against ...; Created on 18 September 2017
34. Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck.: (Publication); Background: Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 ...; Created on 18 September 2017
35. Non-parametric ROC summary statistics: (Publication); Receiver operating characteristic (ROC) curves are useful statistical tools for medi- cal diagnostic testing. It has been proved its capability to assess diagnostic marker’s ability to distinguish between ...; Created on 08 September 2017
36. Deformation analysis in tunnels through curve clustering: (Publication); Deformations in tunnels and galleries due to confinement pressures can occur continuously but also at discrete time intervals. We propose a methodology to detect discrete significant deformations in tunnels ...; Created on 18 September 2017
37. Kaplan-Meier estimator in competing risk contexts: (Publication); Survival analysis has become in a common procedure in biomedical researches. Conventionally, the well-known nonparametric Kaplan-Meier (KM) estimator is used in order to approximate the real survivor curve. ...; Created on 18 September 2017
38. High levels of atrial natriuretic peptide and copeptin and mortality risk: (Publication); Objective: To determine whether high levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin (PCT) plasma concentrations are associated with increased mortality risk. Methods: ...; Created on 18 September 2017
39. Revisiting environmental Kuznets curves through the energy price lens: (Publication); The goal of this paper is to provide new insights to elucidate the inconclusive results from the Environmental Kuznets Curve (EKC) empirical literature. For the first time in empirical literature, an econometric ...; Created on 08 September 2017
40. Boostrap-based procedures for inference in nonparametric ROC regression analysis: (Publication); Before the use of a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is an essential step. The receiver operating characteristic (ROC) curve is the measure ...; Created on 10 December 2016
41. Cumulative/dynamic ROC curve estimation: (Publication); Receiver operating-characteristic (ROC) curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent ...; Created on 04 November 2016
42. Nonparametric estimation of time-dependent ROC curves conditional on a continuous covariate: (Publication); The receiver-operating characteristic (ROC) curve is the most widely used measure for evaluating the performance of a diagnostic biomarker when predicting a binary disease outcome. The ROC curve displays ...; Created on 04 November 2016
43. Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2007 and 2011 staging systems: a pooled analysis of individual patient data: (Publication); Background There is no universal consensus on the best staging system for chronic obstructive pulmonary disease (COPD). Although documents (eg, the Global Initiative for Chronic Obstructive Lung Disease ...; Created on 01 September 2017
44. Application of generalized additive models to the evaluation of continuous markers for classifcation purposes: (Publication); Background: Receiver operating characteristic (ROC) curve and derived measures as the Area Under the Curve (AUC) are often used for evaluating the discriminatory capability of a continuous biomarker in ...; Created on 01 September 2017
45. Asessing the suitability of the minimum capture size and protection regimes in the gooseneck barnacle shellfishery: (Publication); The suitability of a total-length-based, minimum capture-size and different protection regimes was investigated for the gooseneck barnacle Pollicipes pollicipes shellfishery in N Spain. For this analysis, ...; Created on 01 September 2017
46. Seasonality, ambient temperatures and hospitalizations for acute exacerbation of COPD: a metropolitan area population-based study: (Publication); Background: Excluding the tropics, exacerbations of chronic obstructive pulmonary disease (COPD) are more frequent in winter. However, studies that directly relate hospitalizations for exacerbation of ...; Created on 01 September 2017
47. A case-deletion diagnostic for penalized calibration estimators and BLUP under linear mixed models in survey sampling: (Publication); The penalized calibration technique in survey sampling combines usual calibration and soft calibration by introducing a penalty term. Certain relevant estimates in survey sampling can be considered as ...; Created on 31 August 2017
48. A Bootstrap-Based Covariate Selection Method for Modelling the Risk of Lightning-Induced Fires at a Local Scale: A Case Study in Northwest Spain: (Publication); In lightning-induced fire risk prediction models, the number of potential predictors is usually high, with some redundancy among them. It is therefore important to select the best subset of predictors ...; Created on 04 September 2017
49. Quality control in aerobiology: comparison different slide reading methods: (Publication); The use of standard methodology allows us to compare and to evaluate the data generated from samplers under general use. In aerobiological pollen monitoring, the most frequently slide sampling methods ...; Created on 04 September 2017
50. An R Package For Analyzing Factor‐By‐Curve Interactions: (Publication); Analysis of such studies can be successfully performed using nonparametric regression models. In the nonparametric regression framework, issues of interest include the so‐called factor‐by‐curve interaction, ...; Created on 21 September 2017