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1. The role of the p-value in the multitesting problem: (Publication); Modern science frequently involves the analysis of large amount of quantitative information and the simultaneous testing of thousands or even hundreds of thousands null hypotheses. In this context, sometimes, ...; Created on 22 November 2019
2. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 25 September 2019
3. On the optimism correction of the area under the receiver operating characteristic curve in logistic prediction models: (Publication); When the same data are used to fit a model and estimate its predictive performance, this estimate may be optimistic, and its correction is required. The aim of this work is to compare the behaviour of ...; Created on 25 September 2019
4. A method for determining groups in multiple survival curves: (Publication); Survival analysis includes a wide variety of methods for analyzing time‐to‐event data. One basic but important goal in survival analysis is the comparison of survival curves between groups. Several nonparametric ...; Created on 23 August 2019
5. Testing critical points of nonparametric regression curves: application to the management of stalked barnacles: (Publication); Several aquatic living resources are overexploited. An example of this is a barnacle fishery, which is a commercial species that commands high prices in the market. We feel that not enough is known about ...; Created on 23 August 2019
6. Circulating microRNAs in suspected stable coronary artery disease: A coronary computed tomography angiography study: (Publication); Objectives To explore the diagnostic performance of circulating microRNAs (miRNAs) as biomarkers in patients with suspected stable coronary artery disease (CAD). Methods Plasma samples were collected ...; Created on 22 August 2019
7. Plasma microRNA Profiling Reveals Novel Biomarkers of Epicardial Adipose Tissue: A Multidetector Computed Tomography Study: (Publication); Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and a target for therapy. Here, we evaluated for the first time the plasma microRNA (miRNA) profile as ...; Created on 22 August 2019
8. Improving the biomarker diagnostic capacity via functional transformations: (Publication); The use of the area under the receiver-operating characteristic, ROC, curve (AUC) as an index of diagnostic accuracy is overwhelming in fields such as biomedical science and machine learning. It seems ...; Created on 22 August 2019
9. External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study: (Publication); The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the ...; Created on 22 August 2019
10. The Youden Index in the Generalized Receiver Operating Characteristic Curve Context: (Publication); The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker ...; Created on 22 August 2019
11. Testing equality of a large number of densities under mixing conditions: (Publication); In certain settings, such as microarray data, the sampling information is formed by a large number of possibly dependent small data sets. In special applications, for example in order to perform clustering, ...; Created on 12 December 2018
12. Bootstrap-based testing approaches for the assessment of the diagnostic accuracy of biomarkers subject to a limit of detection: (Publication); Assessment of the diagnostic accuracy of biomarkers through receiver operating characteristic curve analysis frequently involves a limit of detection imposed by the laboratory analytical system precision. ...; Created on 09 October 2018
13. Diagnostic accuracy of STOP-Bang questionnaire on moderate sleep apnoea in primary care: (Publication); OBJECTIVE: We aimed to compare the diagnostic utility of the STOP-Bang questionnaire for moderate apnoea against the gold standard (type I polysomnography) in a primary care setting. METHOD: Study of ...; Created on 02 October 2018
14. Parametric estimates for the receiver operating characteristic curve generalization for non-monotone relationships: (Publication); Diagnostic procedures are based on establishing certain conditions and then checking if those conditions are satisfied by a given individual. When the diagnostic procedure is based on a continuous marker, ...; Created on 22 May 2018
15. Bayesian nonparametric inference for the covariate-adjusted ROC curve: (Publication); Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between ...; Created on 10 October 2018
16. nsROC: An R package for non-standard ROC curve analysis: (Publication); The receiver operating characteristic (ROC) curve is a graphical method which has become standard in the analysis of diagnostic markers, that is, in the study of the classiﬁcation ability of a numerical ...; Created on 10 October 2018
17. A Diagnostic Test Approach for Multitesting Problems: (Publication); In the last decades, multiple-testing problems have received much attention. Many different methods have been proposed in order to deal with this relevant issue. Most of them are focused on controlling ...; Created on 10 October 2018
18. THU0359 Relationship between damage clustering and mortality in juvenile systemic lupus erythematosus: cluster analyses in a large cohort from the spanish society of rheumatology lupus registry: (Publication); Background/Purpose: To identify patterns (clusters) of damage manifestation within a large cohort of juvenile SLE (jSLE) patients and evaluate their possible association with mortality. Methods: This ...; Created on 08 October 2018
19. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 02 October 2018
20. Efficient nonparametric confidence bands for receiver operating-characteristic curves: (Publication); Receiver operating-characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous (bio)markers. In spite of the existence of a huge number of ...; Created on 01 October 2018
21. A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples o: (Publication); Background: Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive ...; Created on 22 May 2018
22. Improving stability of prediction models based on correlated omics data by using network approaches: (Publication); Building prediction models based on complex omics datasets such as transcriptomics, proteomics, metabolomics remains a challenge in bioinformatics and biostatistics. Regularized regression techniques are ...; Created on 22 May 2018
23. Performance of BRCA1/2 mutation prediction models in male breast cancer patients: (Publication); To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of ...; Created on 22 May 2018
24. Bootstrap-based procedures for inference in nonparametric receiver-operating characteristic curve regression analysis: (Publication); Prior to using a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is essential. The receiver-operating characteristic curve is the measure of accuracy most ...; Created on 22 May 2018
25. Levels of anti-CMV antibodies are modulated by the frequency and intensity of virus reactivations in kidney transplant patients: (Publication); Anti-CMV (cytomegalovirus) antibody titers are related to immune alterations and increased risk of mortality. To test whether they represent a marker of infection history, we analyzed the effect of viral ...; Created on 22 May 2018
26. Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease: (Publication); Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive ...; Created on 22 May 2018
27. Smooth time-dependent receiver operating characteristic curve estimators: (Publication); The receiver operating characteristic curve is a popular graphical method often used to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent variable, ...; Created on 22 May 2018
28. A new approach to categorising continuous variables in prediction models: Proposal and validation: (Publication); When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded ...; Created on 22 May 2018
29. Wavelet estimation of density for censored data with censoring indicator missing at random: (Publication); In this paper, we define the nonlinear wavelet estimator of density for the right censoring model with the censoring indicator missing at random (MAR), and develop its asymptotic expression for mean integrated ...; Created on 22 May 2018
30. npregfast: an R package for nonparametric estimation and inference in life sciences: (Publication); We present the R npregfast package via some applications involved with the study of living organisms. The package implements nonparametric estimation procedures in regression models with or without factor-by-curve ...; Created on 18 September 2017
31. Intestinal microbiota and weight-gain in preterm neonates: (Publication); The involvement of the gut microbiota on weight-gain and its relationship with childhood undernutrition and growth has been reported. Thus, the gut microbiota constitutes a potential therapeutic target ...; Created on 18 September 2017
32. Fully non-parametric receiver operating characteristic curve estimation for random-effects meta-analysis: (Publication); Meta-analyses, broadly defined as the quantitative review and synthesis of the results of related but independent comparable studies, allow to know the state of the art of one considered topic. Since the ...; Created on 18 September 2017
33. Receiver operating characteristic curve generalization for non-monotone relationships: (Publication); The receiver operating characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous markers. It represents in a plot true-positive rates against ...; Created on 18 September 2017
34. Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck.: (Publication); Background: Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 ...; Created on 18 September 2017
35. Non-parametric ROC summary statistics: (Publication); Receiver operating characteristic (ROC) curves are useful statistical tools for medi- cal diagnostic testing. It has been proved its capability to assess diagnostic marker’s ability to distinguish between ...; Created on 08 September 2017
36. Deformation analysis in tunnels through <span class="highlight">curve clustering</span> ...: (Publication); ... based on a probabilistic model-based curve clustering. An EM (expectation-maximization) algorithm is used to obtain the parameters of the component density functions that maximize the log-likelihood function. ...; Created on 18 September 2017
37. Kaplan-Meier estimator in competing risk contexts: (Publication); Survival analysis has become in a common procedure in biomedical researches. Conventionally, the well-known nonparametric Kaplan-Meier (KM) estimator is used in order to approximate the real survivor curve. ...; Created on 18 September 2017
38. High levels of atrial natriuretic peptide and copeptin and mortality risk: (Publication); Objective: To determine whether high levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin (PCT) plasma concentrations are associated with increased mortality risk. Methods: ...; Created on 18 September 2017
39. Revisiting environmental Kuznets curves through the energy price lens: (Publication); The goal of this paper is to provide new insights to elucidate the inconclusive results from the Environmental Kuznets Curve (EKC) empirical literature. For the first time in empirical literature, an econometric ...; Created on 08 September 2017
40. Boostrap-based procedures for inference in nonparametric ROC regression analysis: (Publication); Before the use of a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is an essential step. The receiver operating characteristic (ROC) curve is the measure ...; Created on 10 December 2016
41. Cumulative/dynamic ROC curve estimation: (Publication); Receiver operating-characteristic (ROC) curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent ...; Created on 04 November 2016
42. Nonparametric estimation of time-dependent ROC curves conditional on a continuous covariate: (Publication); The receiver-operating characteristic (ROC) curve is the most widely used measure for evaluating the performance of a diagnostic biomarker when predicting a binary disease outcome. The ROC curve displays ...; Created on 04 November 2016
43. Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology ...: (Publication); Objectives: To identify patterns (clusters) of damage manifestations within a large cohort of SLE patients and evaluate the potential association of these clusters with a higher risk of mortality. Methods: ...; Created on 24 October 2016
44. Application of generalized additive models to the evaluation of continuous markers for classifcation purposes: (Publication); Background: Receiver operating characteristic (ROC) curve and derived measures as the Area Under the Curve (AUC) are often used for evaluating the discriminatory capability of a continuous biomarker in ...; Created on 01 September 2017
45. A Bootstrap-Based Covariate Selection Method for Modelling the Risk of Lightning-Induced Fires at a Local Scale: A Case Study in Northwest Spain: (Publication); In lightning-induced fire risk prediction models, the number of potential predictors is usually high, with some redundancy among them. It is therefore important to select the best subset of predictors ...; Created on 04 September 2017
46. An R Package For Analyzing Factor‐By‐Curve Interactions: (Publication); Analysis of such studies can be successfully performed using nonparametric regression models. In the nonparametric regression framework, issues of interest include the so‐called factor‐by‐curve interaction, ...; Created on 21 September 2017
47. ROC curve and covariates: extending induced methodology to the non-parametric framework: (Publication); Continuous diagnostic tests are often used to discriminate between diseased and healthy populations. The receiver operating characteristic (ROC) curve is a widely used tool that provides a graphical visualisation ...; Created on 08 September 2017
48. Assessing neural activity related to decision-making through flexible odds ratio curves and their derivatives: (Publication); It is well established that neural activity is stochastically modulated over time. Therefore, direct comparisons across experimental conditions and determination of change points or maximum firing rates ...; Created on 08 September 2017
49. A new flexible direct ROC regression model: Application to the detection of cardiovascular risk factors by anthropometric measures: (Publication); The receiver operating characteristic (ROC) curve is the most widely used measure for evaluating the accuracy of diagnostic tests in terms of differentiating between two conditions. It is known that, in ...; Created on 08 September 2017
50. An R Package For Analyzing Factor‐By‐Curve Interactions: (Publication); Analysis of such studies can be successfully performed using nonparametric regression models. In the nonparametric regression framework, issues of interest include the so‐called factor‐by‐curve interaction, ...; Created on 08 September 2017