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1. Addition of a 161-SNP polygenic risk score to family history-based risk prediction: Impact on clinical management in non- BRCA1/2 breast cancer families: (Publication); Background The currently known breast cancer-associated single nucleotide polymorphisms (SNPs) are presently not used to guide clinical management. We explored whether a genetic test that incorporates ...; Created on 26 September 2019
2. An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome: (Publication); Purpose: Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members ...; Created on 26 September 2019
3. Plasma microRNAs as biomarkers for Lamin A/C-related dilated cardiomyopathy: (Publication); Lamin A/C gene (LMNA)-related familial dilated cardiomyopathy (fDCM) is an aggressive heart disease that often leads to transplantation and sudden death. The aim of our study was to evaluate the circulating ...; Created on 01 October 2018
4. Improving stability of prediction models based on correlated omics data by using network approaches: (Publication); Building prediction models based on complex omics datasets such as transcriptomics, proteomics, metabolomics remains a challenge in bioinformatics and biostatistics. Regularized regression techniques are ...; Created on 22 May 2018
5. Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease: (Publication); Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive ...; Created on 22 May 2018
6. Measuring the efficiency of the Spanish Olympic Sports Federations: (Publication); Research question: The most common result in the analysis of efficiency in multisport competitions like the Olympic Games using the data envelopment analysis (DEA) is a ranking of the participating countries. ...; Created on 18 September 2017
7. Relationship between serum levels of VIP, but not of CGRP, and cranial autonomic parasympathetic symptoms: A study in chronic migraine patients: (Publication); Background: Cranial autonomic parasympathetic symptoms (CAPS) appear in at least half of migraine patients theoretically as a result of the release of peptides by the trigemino-vascular system (TVS). Cranial ...; Created on 18 September 2017
8. A single nucleotide polymorphism in the Il17ra promoter is associated with functional severity of Ankylosing Spondylitis: (Publication); The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis ...; Created on 07 November 2016
9. Circulating microRNAs in Huntington's disease: Emerging mediators in metabolic impairment: (Publication); Huntington’s disease (HD) is a hereditary neurodegenerative disease, with peripheral consequences that negatively contribute to quality of life. Circulating microRNAs (cmiRNAs) are being explored for their ...; Created on 07 November 2016
10. Clinical significance of ANOCTAMIN-1 gene at 11q13 in the development and progression of head and neq aquamous cell carcinomas: (Publication); This study investigates the clinical significance of Anoctamin-1 gene mapping at 11q13 amplicon in both the development and progression of head and neck squamous cell carcinomas (HNSCC). ANO1 protein expression ...; Created on 01 September 2017
11. OnabotulinumtoxinA decreases interictal CGRP plasma levels in chronic migraine patients: (Publication); OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in ...; Created on 01 September 2017
12. Performance of Beta-Binomial SGoF Multitesting Method for Dependent Gene Expression Levels A Simulation Study: (Publication); In a recent paper (de Uña-Álvarez, 2012, Statistical Applications in Genetics and Molecular Biology Vol. 11, Iss. 3, Article 14) a correction of SGoF multitesting method for possibly dependent tests was ...; Created on 14 January 2019
13. The Beta-Binomial SGoF for multiple dependent tests: (Publication); In this paper a correction of SGoF multitesting method for dependent tests is introduced. The correction is based in the beta-binomial model, and therefore the new method is called Beta-Binomial SGoF ...; Created on 08 September 2017
14. A Simulation Study on the Impact of Strong Dependence in High-Dimensional Multiple-Testing I: The Case without Effects: (Publication); When working with high-dimensional biological data the so-called multiple hypothesis testing problem emerges. That is, when many separate tests are performed, several will be significant by chance provoking ...; Created on 10 January 2019
15. Cooperative game theory and inventory management: (Publication); Supply chain management is related to the coordination of materials, products and information flows among suppliers, manufacturers, distributors, retailers and customers involved in producing and delivering ...; Created on 08 September 2017
16. Neural network models for assesing road suitability for dangerous goods transport: (Publication); Created on 12 September 2017