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1. Multiscale supervised classification of point clouds with urban and forest applications: (Publication); We analyze the utility of multiscale supervised classification algorithms for object detection and extraction from laser scanning or photogrammetric point clouds. Only the geometric information (the point ...; Created on 22 November 2019
2. Traditional Processed Meat Products Re-designed Towards Inulin-rich Functional Foods Reduce Polyps in Two Colorectal Cancer Animal Models: (Publication); Inulin-rich foods exert a prebiotic effect, as this polysaccharide is able to enhance beneficial colon microbiota populations, giving rise to the in situ production of short-chain fatty acids (SCFAs) such ...; Created on 22 November 2019
3. Methylation Assessment for the Prediction of Malignancy in Mediastinal Adenopathies Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Patients with Lung Cancer: (Publication); The evaluation of mediastinal lymph nodes is critical for the correct staging of patients with lung cancer (LC). Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally ...; Created on 26 September 2019
4. Assessing a single SNP located at TERT/CLPTM1L multi-cancer risk region as a genetic modifier for risk of pancreatic cancer and melanoma in Dutch CDKN2A mutation carriers: (Publication); Carriers of pathogenic variants in CDKN2A have a 70% life-time risk of developing melanoma and 15–20% risk of developing pancreatic cancer (PC). In the Netherlands, a 19-bp deletion in exon 2 of CDKN2A ...; Created on 26 September 2019
5. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 25 September 2019
6. On the optimism correction of the area under the receiver operating characteristic curve in logistic prediction models: (Publication); When the same data are used to fit a model and estimate its predictive performance, this estimate may be optimistic, and its correction is required. The aim of this work is to compare the behaviour of ...; Created on 25 September 2019
7. A Multistate Model for Analyzing Transitions Between Body Mass Index Categories During Childhood: The Generation XXI Birth Cohort Study: (Publication); Prevalences of overweight and obesity in young children have risen dramatically in the last several decades in most developed countries. Childhood overweight and obesity are known to have immediate and ...; Created on 25 September 2019
8. Complete null agent for games with externalities: (Publication); Game theory provides valuable tools to examine expert multi-agent systems. In a cooperative game, collaboration among agents leads to better outcomes. The most important solution for such games is the ...; Created on 25 September 2019
9. Goodness-of-fit tests for quantile regression with missing responses: (Publication); Goodness–of–fit tests for quantile regression models, in the presence of missing observations in the response variable, are introduced and analyzed in this paper. The different proposals are based on the ...; Created on 19 September 2019
10. Predicting pollution incidents through semiparametric quantile regression models: (Publication); In this paper we present a method to forecast pollution episodes using measurements of the pollutant concentration along time. Specifically, we use a backfitting algorithm with local polynomial kernel ...; Created on 18 September 2019
11. Goodness-of-fit tests for parametric specifications of conditionally heteroscedastic models: (Publication); We consider a goodness-of-fit test for certain parametrizations of conditionally heteroscedastic time series with unobserved components. Our test is quite general in that it can be employed to validate ...; Created on 17 September 2019
12. Estimation in the progressive illness-death model: a non-exhaustive review: (Publication); Multistate models can be successfully used for describing complex event history data, for example, describing stages in the disease progression of a patient. The so‐called “illness‐death” model plays a ...; Created on 23 August 2019
13. Testing critical points of nonparametric regression curves: application to the management of stalked barnacles: (Publication); Several aquatic living resources are overexploited. An example of this is a barnacle fishery, which is a commercial species that commands high prices in the market. We feel that not enough is known about ...; Created on 23 August 2019
14. Circulating microRNAs in suspected stable coronary artery disease: A coronary computed tomography angiography study: (Publication); Objectives To explore the diagnostic performance of circulating microRNAs (miRNAs) as biomarkers in patients with suspected stable coronary artery disease (CAD). Methods Plasma samples were collected ...; Created on 22 August 2019
15. Plasma microRNA Profiling Reveals Novel Biomarkers of Epicardial Adipose Tissue: A Multidetector Computed Tomography Study: (Publication); Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and a target for therapy. Here, we evaluated for the first time the plasma microRNA (miRNA) profile as ...; Created on 22 August 2019
16. An instrumental variable procedure for estimating Cox models with non‐proportional hazards in the presence of unmeasured confounding: (Publication); Two‐stage instrumental variable methods are commonly used for estimating average causal effects in the presence of an unmeasured confounder. In the context of the proportional hazard Cox regression models, ...; Created on 22 August 2019
17. External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study: (Publication); The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the ...; Created on 22 August 2019
18. Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma: (Publication); The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there ...; Created on 22 August 2019
19. Hubert's multi‐rater kappa revisited: (Publication); There is a frequent need to measure the degree of agreement among R observers who independently classify n subjects within K nominal or ordinal categories. The most popular methods are usually kappa‐type ...; Created on 06 August 2019
20. Serum phosphate optimal timing and range associated with patients survival in haemodialysis: the COSMOS study: (Publication); Background Serum phosphate is a key parameter in the management of chronic kidney disease-mineral and bone disorder (CKD-MBD). The timing of phosphate measurement is not standardized in the current guidelines. ...; Created on 10 October 2018
21. Characterization of multinormality and corresponding tests of fit, including for GARCH models: (Publication); We provide novel characterizations of multivariate normality that incorporate both the characteristic function and the moment generating function, and we employ these results to construct a class of affine ...; Created on 09 October 2018
22. A two-sample test for the error distribution in nonparametric regression based on the characteristic function: (Publication); A test for the equality of error distributions in two nonparametric regression models is proposed. The test statistic is based on comparing the empirical characteristic functions of the residuals calculated ...; Created on 09 October 2018
23. Bootstrap-based testing approaches for the assessment of the diagnostic accuracy of biomarkers subject to a limit of detection: (Publication); Assessment of the diagnostic accuracy of biomarkers through receiver operating characteristic curve analysis frequently involves a limit of detection imposed by the laboratory analytical system precision. ...; Created on 09 October 2018
24. Body mass index transitions during childhood: a multiple-state model approach: (Publication); Introduction Childhood obesity is of major public health concern with significant health, social and economic impacts, having even potential to reverse the increase in longevity that has been observed. ...; Created on 06 March 2019
25. Percentile curves and reference values for 2000-m rowing ergometer performance time in international rowers aged 14-70 years: (Publication); The aim of this study was to provide percentile curves and reference values for the performance in 2000-m maximal effort on rowing ergometer. A cross-sectional study was carried out with a non-probabilistic ...; Created on 11 October 2018
26. Bayesian nonparametric inference for the covariate-adjusted ROC curve: (Publication); Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between ...; Created on 10 October 2018
27. Inventorymodel: an R Package for Centralized Inventory Problems: (Publication); Inventory management of goods is an integral part of logistics systems; common to various economic sectors such as industry, agriculture and trade; and independent of production volume. In general, as ...; Created on 03 October 2018
28. Sequential double cross-validation for assessment of added predictive ability in high-dimensional OMIC applications: (Publication); Enriching existing predictive models with new biomolecular markers is an important task in the new multi-omic era. Clinical studies increasingly include new sets of omic measurements which may prove their ...; Created on 03 October 2018
29. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 02 October 2018
30. SIMPLIFY ITS An Intelligent Tutoring System based on Cognitive Diagnosis Models and spaced learning: (Publication); In this paper we introduce Simplify ITS, a novel approach to an adaptive and Intelligent Tutoring System (ITS) aimed to support teachers in enhancing the student know ledge and skills. Unlike other approaches, ...; Created on 01 October 2018
31. Penalized profile least squares-based statistical inference for varying coefficient partially linear errors-in-variables models: (Publication); The purpose of this paper is two fold. First, we investigate estimation for varying coefficient partially linear models in which covariates in the nonparametric part are measured with errors. As there ...; Created on 01 October 2018
32. Asymptotic distribution-free tests for semiparametric regressions with dependent data: (Publication); This article proposes a new general methodology for constructing nonparametric and semiparametric Asymptotically Distribution-Free (ADF) tests for semiparametric hypotheses in regression models for possibly ...; Created on 22 May 2018
33. Survival analysis with delayed entry in selected families with application to human longevity: (Publication); In the field of aging research, family-based sampling study designs are commonly used to study the lifespans of long-lived family members. However, the specific sampling procedure should be carefully taken ...; Created on 22 May 2018
34. Improving stability of prediction models based on correlated omics data by using network approaches: (Publication); Building prediction models based on complex omics datasets such as transcriptomics, proteomics, metabolomics remains a challenge in bioinformatics and biostatistics. Regularized regression techniques are ...; Created on 22 May 2018
35. Performance of BRCA1/2 mutation prediction models in male breast cancer patients: (Publication); To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of ...; Created on 22 May 2018
36. Bootstrap-based procedures for inference in nonparametric receiver-operating characteristic curve regression analysis: (Publication); Prior to using a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is essential. The receiver-operating characteristic curve is the measure of accuracy most ...; Created on 22 May 2018
37. Levels of anti-CMV antibodies are modulated by the frequency and intensity of virus reactivations in kidney transplant patients: (Publication); Anti-CMV (cytomegalovirus) antibody titers are related to immune alterations and increased risk of mortality. To test whether they represent a marker of infection history, we analyzed the effect of viral ...; Created on 22 May 2018
38. Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease: (Publication); Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive ...; Created on 22 May 2018
39. Computationally Efficient Goodness-of-Fit Tests for the Error Distribution in Nonparametric Regression: (Publication); Several procedures have been proposed for testing goodness-of-fit to the error distribution in nonparametric regression models. The null distribution of the associated test statistics is usually approximated ...; Created on 14 May 2018
40. Estimation of Transition Probabilities for the Illness-Death Model: Package TP.idm: (Publication); In this paper the R package TP.idm to compute an empirical transition probability matrix for the illness-death model is introduced. This package implements a novel non-parametric estimator which is particularly ...; Created on 14 May 2018
41. Nonparametric Estimation of Transition Probabilities for a General Progressive Multi-State Model Under CrossSectional Sampling: (Publication); Nonparametric estimation of the transition probability matrix of a progressive multi-state model is consideredunder cross-sectional sampling. Two diﬀerent estimators adapted to possibly right-censored ...; Created on 20 February 2018
42. Inverse Probability Weighted Cox Regression for Doubly Truncated Data: (Publication); Doubly truncated data arise when event times are observed only if they fall within subject-specific, possibly random, intervals. While non-parametric methods for survivor function estimation using doubly ...; Created on 20 February 2018
43. Placing joint orders when holding costs are negligible and shortages are not allowed: (Publication); In this paper we analyse multi-agent inventory systems where each agent has a deterministic demand and a capacitated warehouse with constant holding costs. Additionally, shortages are not allowed, the ...; Created on 16 February 2018
44. Determining optimum wavelengths for leaf water content estimation from reflectance: A distance correlation approach: (Publication); This paper proposes a method to estimate leaf water content from reflectance in four commercial vineyard varieties by estimating the local maxima of a distance correlation function. First, it applies four ...; Created on 24 January 2018
45. On coalition formation in a non-convex multi-agent inventory problem: (Publication); A multi-agent inventory problem is a situation in which several agents face individual inventory problems and can coordinate their orders to reduce costs. This paper analyses a multi-agent inventory problem ...; Created on 18 September 2017
46. On the Combination of Omics Data for Prediction of Binary Outcomes: (Publication); Enrichment of predictive models with new biomolecular markers is an important task in high-dimensional omic applications. Increasingly, clinical studies include several sets of such omics markers available ...; Created on 10 October 2018
47. A weighted bootstrap approximation for comparing the error distributions in nonparametric regression: (Publication); Several procedures have been proposed for testing the equality of error distributions in two or more nonparametric regression models. Here we deal with methods based on comparing estimators of the cumulative ...; Created on 09 October 2018
48. Quality of life and anxiety in women with breast cancer before and after treatment.: (Publication); Objectives: to determine the quality of life and anxiety in patients with breast cancer and the changes they experience after treatments. Method: prospective study. Breast cancer statistics (n=339, confidence=95%, ...; Created on 08 October 2018
49. A new approach to categorising continuous variables in prediction models: Proposal and validation: (Publication); When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded ...; Created on 22 May 2018
50. A simple algorithm for the identification of clinical COPD phenotypes: (Publication); This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 COPD patients of ...; Created on 22 May 2018