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1. Structural, Dermal and Ungual Characteristics of the Foot in Patients with Type II Diabetes: (Publication); Background and Objectives: Diabetes is a chronic and metabolic disease, considered as an important public health problem. The objective of this study was to determine the prevalence of podiatric pathology ...; Created on 20 November 2019
2. Addition of a 161-SNP polygenic risk score to family history-based risk prediction: Impact on clinical management in non- BRCA1/2 breast cancer families: (Publication); Background The currently known breast cancer-associated single nucleotide polymorphisms (SNPs) are presently not used to guide clinical management. We explored whether a genetic test that incorporates ...; Created on 26 September 2019
3. Adjusting for bias introduced by instrumental variable estimation in the Cox proportional hazards model: (Publication); Instrumental variable (IV) methods are widely used for estimating average treatment effects in the presence of unmeasured confounders. However, the capability of existing IV procedures, and most notably ...; Created on 25 September 2019
4. Late HIV Diagnosis but Earlier Antiretroviral Treatment Initiation in Northwest Spain: Impact of Current Treatment Guidelines: (Publication); Background: Current HIV treatment guidelines recommend antiretroviral treatment (ART) initiation for all HIV-infected individuals regardless of CD4 count. This study evaluates the immunological and virological ...; Created on 24 September 2019
5. Prevalence of knee osteoarthritis in a random population sample in people aged 40 and over: (Publication); Introduction: Osteoarthritis is the osteoarticular disease with the highest prevalence worldwide. In industrialized countries, 80% of the population > 65 years suffers from it. Objectives: To determine ...; Created on 24 September 2019
6. Concordance between the Different Cardiovascular Risk Scores in People with Rheumatoid Arthritis and Psoriasis Arthritis: (Publication); Aim. To determine the cardiovascular risk and the concordance between the different scores in people with rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Methods. Observational descriptive study ...; Created on 24 September 2019
7. Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: Data from the Osteoarthritis Initiative: (Publication); Objective: To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA). Design: A Nucleic-acid Programmable Protein Arrays (NAPPA) platform ...; Created on 24 September 2019
8. Estimation in the progressive illness-death model: a non-exhaustive review: (Publication); Multistate models can be successfully used for describing complex event history data, for example, describing stages in the disease progression of a patient. The so‐called “illness‐death” model plays a ...; Created on 23 August 2019
9. Systematic review with meta‐analysis: risk factors for recurrent primary sclerosing cholangitis after liver transplantation: (Publication); Background After liver transplantation primary sclerosing cholangitis (PSC), the condition returns in the transplanted liver in a subset of patients (recurrent primary sclerosing cholangitis, rPSC). Aim To ...; Created on 23 August 2019
10. A comparative analysis of long-term mortality after carotid endarterectomy and carotid stenting: (Publication); Background The value of carotid intervention is predicated on long-term survival for patients to derive a stroke prevention benefit. Randomized trials report no significant difference in survival after ...; Created on 22 August 2019
11. Circulating microRNAs in suspected stable <span class="highlight">coronary artery disease</span>: A coronary computed tomography angiography study ...: (Publication); Objectives To explore the diagnostic performance of circulating microRNAs (miRNAs) as biomarkers in patients with suspected stable coronary artery disease (CAD). Methods Plasma samples were collected ...; Created on 22 August 2019
12. Adverse Events After Atherectomy: Analyzing Long‐Term Outcomes of Endovascular Lower Extremity Revascularization Techniques: (Publication); Background The long-term effectiveness of atherectomy treatment for peripheral arterial disease is unknown. We studied 5-year clinical outcomes by endovascular treatment type among patients with peripheral ...; Created on 22 August 2019
13. Long-term Reintervention After Endovascular Abdominal Aortic Aneurysm Repair: (Publication); Objective: To describe the long-term reintervention rate after endovascular abdominal aortic aneurysm repair (EVR), and identify factors predicting reintervention. Summary of Background Data: EVR is ...; Created on 22 August 2019
14. An instrumental variable procedure for estimating Cox models with non‐proportional hazards in the presence of unmeasured confounding: (Publication); Two‐stage instrumental variable methods are commonly used for estimating average causal effects in the presence of an unmeasured confounder. In the context of the proportional hazard Cox regression models, ...; Created on 22 August 2019
15. External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study: (Publication); The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the ...; Created on 22 August 2019
16. Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma: (Publication); The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there ...; Created on 22 August 2019
17. Serum phosphate optimal timing and range associated with patients survival in haemodialysis: the COSMOS study: (Publication); Background Serum phosphate is a key parameter in the management of chronic kidney disease-mineral and bone disorder (CKD-MBD). The timing of phosphate measurement is not standardized in the current guidelines. ...; Created on 10 October 2018
18. Bayesian nonparametric inference for the covariate-adjusted ROC curve: (Publication); Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between ...; Created on 10 October 2018
19. Plasma microRNAs as biomarkers for Lamin A/C-related dilated cardiomyopathy: (Publication); Lamin A/C gene (LMNA)-related familial dilated cardiomyopathy (fDCM) is an aggressive heart disease that often leads to transplantation and sudden death. The aim of our study was to evaluate the circulating ...; Created on 01 October 2018
20. Performance of BRCA1/2 mutation prediction models in male breast cancer patients: (Publication); To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of ...; Created on 22 May 2018
21. Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease: (Publication); Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive ...; Created on 22 May 2018
22. Inverse Probability Weighted Cox Regression for Doubly Truncated Data: (Publication); Doubly truncated data arise when event times are observed only if they fall within subject-specific, possibly random, intervals. While non-parametric methods for survivor function estimation using doubly ...; Created on 20 February 2018
23. Adjusting for bias introduced by instrumental variable estimation in the Cox proportional hazards model: (Publication); Instrumental variable (IV) methods are widely used for estimating average treatment effects in the presence of unmeasured confounders. However, the capability of existing IV procedures, and most notably ...; Created on 10 October 2018
24. Low-voltage chest CT: another way to reduce the radiation dose in asbestos-exposed patients: (Publication); AIM: To assess whether low voltage chest computed tomography (CT) can be used to successfully diagnose disease in patients with asbestos exposure. MATERIALS AND METHODS: Fifty-six former employees ...; Created on 22 May 2018
25. A new approach to categorising continuous variables in prediction models: Proposal and validation: (Publication); When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded ...; Created on 22 May 2018
26. A simple algorithm for the identification of clinical COPD phenotypes: (Publication); This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 COPD patients of ...; Created on 22 May 2018
27. Long-Term Survival After Carotid Endarterectomy and Carotid Stenting: A Propensity-Matched Analysis: (Publication); Survival after carotid endarterectomy (CEA) and carotid artery stenting (CAS) is required for patients to derive a stroke prevention benefit. Randomized trials report no difference, whereas observational ...; Created on 23 January 2018
28. Comparison of two discrimination indexes in the categorisation of continuous predictors in time-to-event studies: (Publication); The Cox proportionalhazards model is the most widely used survival predictionmodel for analysing time-to-event data. To measure the discrimination ability of a survival model the concordance probability ...; Created on 18 September 2017
29. Incidence of cardiovascular events and associated risk factors in kidney transplant patients: a competing risks survival analysis: (Publication); Background: The high prevalence of cardiovascular risk factors among the renal transplant population accounts for increased mortality. The aim of this study is to determine the incidence of cardiovascular ...; Created on 18 September 2017
30. The interdialytic period for blood collection influences serum phosphorus and the risk of mortality in the cosmos study: (Publication); Phosphorus (P), calcium (Ca) and PTH are the main serum biochemical parameters of bone and mineral metabolism used for the current management of Chronic Kidney Disease-Mineral and Bone Disorders (CKD-MBD). ...; Created on 18 September 2017
31. Effect of a Ropy Exopolysaccharide-Producing bifidobacterium animalis subsp lactis strain orally administered on DSS-Induced Colitis mice model: (Publication); Exopolysaccharide (EPS)-producing bifidobacteria, particularly Bifidobacterium animalis subsp. lactis strains, are used in the functional food industry as promising probiotics with purported beneficial ...; Created on 18 September 2017
32. Risk factors for tuberculosis in inflammatory bowel disease: anti-tumor necrosis factor and hospitalization: (Publication); Aims: To determine risk factors for active tuberculosis in patients with inflammatory bowel diseases. Methods: Retrospective, case-control study at 4 referral hospitals in Spain. Cases developed tuberculosis ...; Created on 18 September 2017
33. NO SIGNS OF CEREBRAL SMALL-VESSEL DISEASE ON TRANSCRANIAL DOPPLER IN MIGRAINE PATIENTS: (Publication); Created on 18 September 2017
34. Survival of biological drugs in the treatment of chronic inflammatory arthropathies: (Publication); Objectives: To analyze the survival of treatment lines with different biologics in a cohort of patients diagnosed with rheumatoid arthritis (RA), psoriatic arthritis (AP), ankylosing spondylitis (AS) and ...; Created on 18 September 2017
35. Reasons for Discontinuation The Biological Treatment in Chronic Inflammatory Arthropathy: (Publication); Objectives: To analyze the reasons for discontinuation the biological treatment in a cohort of patients diagnosed with rheumatoid arthritis (RA), psoriatic arthritis (PA), ankylosing spondylitis (AS) and ...; Created on 18 September 2017
36. Is the treatment of Enterobius vermicularis co-infection necessary to eradicate Dientamoeba fragilis infection?: (Publication); Objectives: Dientamoeba fragilis is a pathogenic protozoan of the human gastrointestinal tract with a worldwide distribution, which has emerged as an important and misdiagnosed cause of chronic gastrointestinal ...; Created on 07 November 2016
37. A single nucleotide polymorphism in the Il17ra promoter is associated with functional severity of Ankylosing Spondylitis: (Publication); The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis ...; Created on 07 November 2016
38. Circulating microRNAs in Huntington's disease: Emerging mediators in metabolic impairment: (Publication); Huntington’s disease (HD) is a hereditary neurodegenerative disease, with peripheral consequences that negatively contribute to quality of life. Circulating microRNAs (cmiRNAs) are being explored for their ...; Created on 07 November 2016
39. Prognostic assessment in COPD without lung function: The B-AE-D indices: (Publication); Several composite markers have been proposed for risk assessment in chronic obstructive pulmonary disease (COPD). However, choice of parameters and score complexity restrict clinical applicability. Our ...; Created on 07 November 2016
40. Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas: (Publication); The PI3K/AKT/mTOR signaling pathway has emerged as one of the most frequently deregulated in head and neck squamous cell carcinomas (HNSCC). Numerous alterations of various upstream and downstream components ...; Created on 04 November 2016
41. Nonparametric estimation of the survival function for ordered multivariate failure time data: A comparative study: (Publication); In longitudinal studies of disease, patients may experience several events through a follow-up period. In these studies, the sequentially ordered events are often of interest and lead to problems that ...; Created on 04 November 2016
42. Nonparametric estimation of time-dependent ROC curves conditional on a continuous covariate: (Publication); The receiver-operating characteristic (ROC) curve is the most widely used measure for evaluating the performance of a diagnostic biomarker when predicting a binary disease outcome. The ROC curve displays ...; Created on 04 November 2016
43. Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology ...: (Publication); Objectives: To identify patterns (clusters) of damage manifestations within a large cohort of SLE patients and evaluate the potential association of these clusters with a higher risk of mortality. Methods: ...; Created on 24 October 2016
44. ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma: (Publication); PURPOSE. We previously identified the presence of the melanocyte-specific secreted (ME20-S) glycoprotein in secretomes of uveal melanoma (UM) cultures. The aim of this study was to test for the presence ...; Created on 01 September 2017
45. Expanded renal transplantation: A competing risk model approach: (Publication); Multi-state models (MSMs) are useful to analyze survival data when, besides the event of main interest, one or more intermediate states of the individual are identified. These models take the several existing ...; Created on 01 September 2017
46. Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2007 and 2011 staging systems: a pooled analysis of individual patient data: (Publication); Background There is no universal consensus on the best staging system for chronic obstructive pulmonary disease (COPD). Although documents (eg, the Global Initiative for Chronic Obstructive Lung Disease ...; Created on 01 September 2017
47. Improvement of mineral and bone metabolism markers in associated with better survival in hemodialysis patients: the COSMOS study: (Publication); Abnormalities in serum phosphorus, calcium and parathyroid hormone (PTH) have been associated with poor survival in haemodialysis patients. This COSMOS (Current management Of Secondary hyperparathyroidism: ...; Created on 01 September 2017
48. Increased natural killer cell chemotaxis to CXCL12 in patients with multiple sclerosis: (Publication); Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized by leukocyte infiltration into the central nervous system (CNS). Migration of lymphocyte subpopulations towards CXCL12 ...; Created on 01 September 2017
49. Fast smoothing parameter separation in multidimensional P-splines: The SAP algorithm: (Publication); A new computational algorithm for estimating the smoothing parameters of a multidimensional penalized spline generalized linear model with anisotropic penalty is presented. This new proposal is based on ...; Created on 01 September 2017
50. Application of generalized additive models to the evaluation of continuous markers for classifcation purposes: (Publication); Background: Receiver operating characteristic (ROC) curve and derived measures as the Area Under the Curve (AUC) are often used for evaluating the discriminatory capability of a continuous biomarker in ...; Created on 01 September 2017