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1. The role of the p-value in the multitesting problem: (Publication); Modern science frequently involves the analysis of large amount of quantitative information and the simultaneous testing of thousands or even hundreds of thousands null hypotheses. In this context, sometimes, ...; Created on 22 November 2019
2. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 25 September 2019
3. On the optimism correction of the area under the receiver operating characteristic curve in logistic prediction models ...: (Publication); ... different methods proposed in the literature when correcting for the optimism of the estimated area under the receiver operating characteristic curve in logistic regression models. A simulation study (where ...; Created on 25 September 2019
4. Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: Data from the Osteoarthritis Initiative: (Publication); Objective: To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA). Design: A Nucleic-acid Programmable Protein Arrays (NAPPA) platform ...; Created on 24 September 2019
5. A two-sample test for the equality of univariate marginal distributions for high-dimensional data: (Publication); A recurring theme in modern statistics is dealing with high-dimensional data whose main feature is a large number, p, of variables but a small sample size. In this context our aim is to address the problem ...; Created on 23 September 2019
6. A method for determining groups in multiple survival curves: (Publication); Survival analysis includes a wide variety of methods for analyzing time‐to‐event data. One basic but important goal in survival analysis is the comparison of survival curves between groups. Several nonparametric ...; Created on 23 August 2019
7. Testing critical points of nonparametric regression curves: application to the management of stalked barnacles: (Publication); Several aquatic living resources are overexploited. An example of this is a barnacle fishery, which is a commercial species that commands high prices in the market. We feel that not enough is known about ...; Created on 23 August 2019
8. Circulating microRNAs in suspected stable coronary artery disease: A coronary computed tomography angiography study: (Publication); Objectives To explore the diagnostic performance of circulating microRNAs (miRNAs) as biomarkers in patients with suspected stable coronary artery disease (CAD). Methods Plasma samples were collected ...; Created on 22 August 2019
9. Plasma microRNA Profiling Reveals Novel Biomarkers of Epicardial Adipose Tissue: A Multidetector Computed Tomography Study: (Publication); Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and a target for therapy. Here, we evaluated for the first time the plasma microRNA (miRNA) profile as ...; Created on 22 August 2019
10. Improving the biomarker diagnostic capacity via functional transformations: (Publication); The use of the area under the receiver-operating characteristic, ROC, curve (AUC) as an index of diagnostic accuracy is overwhelming in fields such as biomedical science and machine learning. It seems ...; Created on 22 August 2019
11. External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study: (Publication); The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the ...; Created on 22 August 2019
12. The Youden Index in the Generalized Receiver Operating Characteristic Curve Context ...: (Publication); The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker ...; Created on 22 August 2019
13. A model specification test for the variance function in nonparametric regression: (Publication); The problem of testing for the parametric form of the conditional variance is considered in a fully nonparametric regression model. A test statistic based on a weighted L2-distance between the empirical ...; Created on 09 October 2018
14. Characterization of multinormality and corresponding tests of fit, including for GARCH models: (Publication); We provide novel characterizations of multivariate normality that incorporate both the characteristic function and the moment generating function, and we employ these results to construct a class of affine ...; Created on 09 October 2018
15. Approximating the null distribution of a class of statistics for testing independence: (Publication); A class of tests for testing independence whose test statistic is an -norm of the difference between the joint empirical characteristic function and the product of the marginal empirical characteristic ...; Created on 09 October 2018
16. A two-sample test for the error distribution in nonparametric regression based on the characteristic function: (Publication); A test for the equality of error distributions in two nonparametric regression models is proposed. The test statistic is based on comparing the empirical characteristic functions of the residuals calculated ...; Created on 09 October 2018
17. Bootstrap-based testing approaches for the assessment of the diagnostic accuracy of biomarkers subject to a limit of detection: (Publication); Assessment of the diagnostic accuracy of biomarkers through receiver operating characteristic curve analysis frequently involves a limit of detection imposed by the laboratory analytical system precision. ...; Created on 09 October 2018
18. Diagnostic accuracy of STOP-Bang questionnaire on moderate sleep apnoea in primary care: (Publication); OBJECTIVE: We aimed to compare the diagnostic utility of the STOP-Bang questionnaire for moderate apnoea against the gold standard (type I polysomnography) in a primary care setting. METHOD: Study of ...; Created on 02 October 2018
19. Parametric estimates for the receiver operating characteristic curve generalization for non-monotone relationships ...: (Publication); ... this is equivalent to fix a region or classification subset and then check if the observed value of the marker belongs to that region. Receiver operating characteristic curve is a valuable and popular ...; Created on 22 May 2018
20. Bayesian nonparametric inference for the covariate-adjusted ROC curve: (Publication); Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between ...; Created on 10 October 2018
21. nsROC: An R package for non-standard ROC curve analysis: (Publication); The receiver operating characteristic (ROC) curve is a graphical method which has become standard in the analysis of diagnostic markers, that is, in the study of the classiﬁcation ability of a numerical ...; Created on 10 October 2018
22. A Diagnostic Test Approach for Multitesting Problems: (Publication); In the last decades, multiple-testing problems have received much attention. Many different methods have been proposed in order to deal with this relevant issue. Most of them are focused on controlling ...; Created on 10 October 2018
23. On the estimation of variance parameters in non-standard generalised linear mixed models: application to penalised smoothing: (Publication); We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (J Am Stat Assoc 72(358):320–338, 1977)’s work, but it is able ...; Created on 02 October 2018
24. Efficient nonparametric confidence bands for receiver operating-characteristic curves: (Publication); Receiver operating-characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous (bio)markers. In spite of the existence of a huge number of ...; Created on 01 October 2018
25. Performance of BRCA1/2 mutation prediction models in male breast cancer patients: (Publication); To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of ...; Created on 22 May 2018
26. Bootstrap-based procedures for inference in nonparametric receiver-operating characteristic curve regression analysis: (Publication); Prior to using a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is essential. The receiver-operating characteristic curve is the measure of accuracy most ...; Created on 22 May 2018
27. Levels of anti-CMV antibodies are modulated by the frequency and intensity of virus reactivations in kidney transplant patients: (Publication); Anti-CMV (cytomegalovirus) antibody titers are related to immune alterations and increased risk of mortality. To test whether they represent a marker of infection history, we analyzed the effect of viral ...; Created on 22 May 2018
28. Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease: (Publication); Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive ...; Created on 22 May 2018
29. Smooth time-dependent receiver operating characteristic curve estimators ...: (Publication); The receiver operating characteristic curve is a popular graphical method often used to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent variable, ...; Created on 22 May 2018
30. On the estimation of the characteristic function in finite populations with applications: (Publication); This paper studies the estimation of the characteristic function of a finite population. Specifically, the weak convergence of the finite population empirical characteristic process is studied. Under suitable ...; Created on 14 May 2018
31. Computationally Efficient Goodness-of-Fit Tests for the Error Distribution in Nonparametric Regression: (Publication); Several procedures have been proposed for testing goodness-of-fit to the error distribution in nonparametric regression models. The null distribution of the associated test statistics is usually approximated ...; Created on 14 May 2018
32. A new approach to categorising continuous variables in prediction models: Proposal and validation: (Publication); ... area under the receiver operating characteristic curve (AUC). The proposed methodology is validated when the optimal cut points' location is known in theory or in practice. In addition, the proposed method ...; Created on 22 May 2018
33. Wavelet estimation of density for censored data with censoring indicator missing at random: (Publication); In this paper, we define the nonlinear wavelet estimator of density for the right censoring model with the censoring indicator missing at random (MAR), and develop its asymptotic expression for mean integrated ...; Created on 22 May 2018
34. Empirical characteristic function tests for GARCH innovation distribution using multipliers: (Publication); Goodness-of-fit tests for the innovation distribution in GARCH models based on measuring deviations between the empirical characteristic function of the residuals and the characteristic function under ...; Created on 23 January 2018
35. npregfast: an R package for nonparametric estimation and inference in life sciences: (Publication); We present the R npregfast package via some applications involved with the study of living organisms. The package implements nonparametric estimation procedures in regression models with or without factor-by-curve ...; Created on 18 September 2017
36. Fully non-parametric receiver operating characteristic curve estimation for random-effects meta-analysis ...: (Publication); ... a bivariate estimation for the sensitivity and the specificity by using only one threshold per included study. Frequently, an overall receiver operating characteristic curve based on a bivariate normal ...; Created on 18 September 2017
37. Receiver operating characteristic curve generalization for non-monotone relationships ...: (Publication); The receiver operating characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous markers. It represents in a plot true-positive rates against ...; Created on 18 September 2017
38. Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck.: (Publication); ... with cSCC. Cumulative/dynamic receiver operating characteristic curve was used to determine the optimal PD-L1 threshold. Kaplan-Meier estimators and Cox proportional hazards regression models were also ...; Created on 18 September 2017
39. Fast tests for the two-sample problem based on the empirical characteristic function: (Publication); A class of tests for the two-sample problem whose test statistic is an L2 norm of the difference of the empirical characteristic functions of the samples is considered. The null distribution can be estimated ...; Created on 18 September 2017
40. A class of tests for the two-sample problem for count data: (Publication); A class of tests for the two-sample problem for count data whose test statistic is an L2-norm of the difference between the empirical probability generating functions associated with each sample is considered. ...; Created on 18 September 2017
41. Non-parametric ROC summary statistics: (Publication); Receiver operating characteristic (ROC) curves are useful statistical tools for medi- cal diagnostic testing. It has been proved its capability to assess diagnostic marker’s ability to distinguish between ...; Created on 08 September 2017
42. Tests for conditional ellipticity in multivariate GARCH models: (Publication); Tests are proposed for the assumption that the conditional distribution of a multivariate GARCH process is elliptic. These tests are of Kolmogorov–Smirnov and Cramér–von Mises-type and make use of the ...; Created on 18 January 2017
43. Deformation analysis in tunnels through curve clustering: (Publication); Deformations in tunnels and galleries due to confinement pressures can occur continuously but also at discrete time intervals. We propose a methodology to detect discrete significant deformations in tunnels ...; Created on 18 September 2017
44. Kaplan-Meier estimator in competing risk contexts: (Publication); Survival analysis has become in a common procedure in biomedical researches. Conventionally, the well-known nonparametric Kaplan-Meier (KM) estimator is used in order to approximate the real survivor curve. ...; Created on 18 September 2017
45. High levels of atrial natriuretic peptide and copeptin and mortality risk: (Publication); Objective: To determine whether high levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin (PCT) plasma concentrations are associated with increased mortality risk. Methods: ...; Created on 18 September 2017
46. Revisiting environmental Kuznets curves through the energy price lens: (Publication); The goal of this paper is to provide new insights to elucidate the inconclusive results from the Environmental Kuznets Curve (EKC) empirical literature. For the first time in empirical literature, an econometric ...; Created on 08 September 2017
47. Boostrap-based procedures for inference in nonparametric ROC regression analysis: (Publication); Before the use of a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is an essential step. The receiver operating characteristic (ROC) curve is the measure ...; Created on 10 December 2016
48. Cumulative/dynamic ROC curve estimation: (Publication); Receiver operating-characteristic (ROC) curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent ...; Created on 04 November 2016
49. Fourier methods for model selection: (Publication); A test approach to the model selection problem based on characteristic functions (CFs) is proposed. The scheme is close to that proposed by Vuong (Econometrica 57:257–306, 1989), which is based on comparing ...; Created on 04 November 2016
50. Nonparametric estimation of time-dependent ROC curves conditional on a continuous covariate: (Publication); The receiver-operating characteristic (ROC) curve is the most widely used measure for evaluating the performance of a diagnostic biomarker when predicting a binary disease outcome. The ROC curve displays ...; Created on 04 November 2016