Facultade de Fisioterapia

The Beta-Binomial SGoF for multiple dependent tests

de Uña-Álvarez, Jacobo
Abstract:
In this paper a correction of SGoF multitesting method for dependent tests is introduced. The correction is based in the beta-binomial model, and therefore the new method is called Beta-Binomial SGoF (or BB-SGoF). Main properties of the new method are established, and its practical implementation is discussed. BB-SGoF is illustrated through the analysis of two different real data sets on gene/protein expression levels. The performance of the method is investigated through simulations too. One of the main conclusions of the paper is that SGoF strategy may have much power even in the presence of possible dependences among the tests.
Year:
2012
Type of Publication:
Article
Journal:
Statistical Applications in Genetics and Molecular Biology
Volume:
11
Number:
3
Pages:
14
Month:
May
DOI:
http://dx.doi.org/10.1515/1544-6115.1812
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