Facultade de Fisioterapia

The Youden Index in the Generalized Receiver Operating Characteristic Curve Context

Martínez Camblor, Pablo; Pardo Fernández, Juan Carlos
Abstract:
The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker to distinguish between two populations. This paper presents the concept of Youden index in the context of the generalized ROC (gROC) curve for non-monotone relationships. The interval estimation of the Youden index and the associated cutoff points in a parametric (binormal) and a non-parametric setting is considered. Monte Carlo simulations and a real-world application illustrate the proposed methodology.
Year:
2019
Type of Publication:
Article
Keywords:
Biomarkers; cutoff point; generalized receiver-operating characteristic gROC curve; receiver-operating characteristic ROC curve; Youden index
Journal:
The International Journal of Biostatistics
Volume:
15
Number:
1
Pages:
20180060
Month:
In press
ISSN:
1557-4679 (Online)
Note:
Q2 50/123 h-index 1,309 (JCR2018)
DOI:
https://doi.org/10.1515/ijb-2018-0060
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