The Youden Index in the Generalized Receiver Operating Characteristic Curve Context

Martínez Camblor, Pablo; Pardo Fernández, Juan Carlos

Abstract:

The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker to distinguish between two populations. This paper presents the concept of Youden index in the context of the generalized ROC (gROC) curve for non-monotone relationships. The interval estimation of the Youden index and the associated cutoff points in a parametric (binormal) and a non-parametric setting is considered. Monte Carlo simulations and a real-world application illustrate the proposed methodology.

Year:

2019

Type of Publication:

Article

Keywords:

Biomarkers; cutoff point; generalized receiver-operating characteristic gROC curve; receiver-operating characteristic ROC curve; Youden index

Journal:

The International Journal of Biostatistics

Volume:

15

Number:

1

Pages:

20180060

Month:

In press

ISSN:

1557-4679 (Online)

Note:

Q2 50/123 h-index 1,309 (JCR2018)

DOI:

https://doi.org/10.1515/ijb-2018-0060