Facultade de Fisioterapia

Parametric estimates for the receiver operating characteristic curve generalization for non-monotone relationships

Martínez Camblor, Pablo; Pardo Fernández, Juan Carlos
Abstract:
Diagnostic procedures are based on establishing certain conditions and then checking if those conditions are satisfied by a given individual. When the diagnostic procedure is based on a continuous marker, this is equivalent to fix a region or classification subset and then check if the observed value of the marker belongs to that region. Receiver operating characteristic curve is a valuable and popular tool to study and compare the diagnostic ability of a given marker. Besides, the area under the receiver operating characteristic curve is frequently used as an index of the global discrimination ability. This paper revises and widens the scope of the receiver operating characteristic curve definition by setting the classification subsets in which the final decision is based in the spotlight of the analysis. We revise the definition of the receiver operating characteristic curve in terms of particular classes of classification subsets and then focus on a receiver operating characteristic curve generalization for situations in which both low and high values of the marker are associated with more probability of having the studied characteristic. Parametric and non-parametric estimators of the receiver operating characteristic curve generalization are investigated. Monte Carlo studies and real data examples illustrate their practical performance.
Year:
2019
Type of Publication:
Article
Keywords:
Receiver operating characteristic curve generalization; parametric estimation; non-parametric estimation; asymptotic distribution
Journal:
Statistical Methods in Medical Research
Volume:
28
Number:
7
Pages:
2032-2048
Month:
July
Note:
Q1 17/23 h-index 2,284 (JCR2017)
Comments:
This work was supported by the Grants FC-15-GRUPIN14-101 from the Asturies Government and MTM2014-55966-P of the Spanish Ministry of Economy and Competitiveness.
DOI:
https://journals.sagepub.com/doi/10.1177/0962280217747009
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