Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck.

Pedrero, J. M. García; Martínez Camblor, Pablo; Diaz Coto, S.; Munguia Calzada, P.; Vallina Álvarez, A.; Vazquez López, F.; Rodrigo, J.P.; Santos Juanes, J.

Abstract:

Background: Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 expression has been associated with poor outcome in a wide variety of cancers; however, data in cutaneous squamous cell carcinoma (cSCC) are scarce and conflicting. Objective: To investigate the relationship of tumor PD-L1 expression with the clinicopathologic features and prognosis of cSCC. Methods: PD-L1 expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 100 patients with cSCC. Cumulative/dynamic receiver operating characteristic curve was used to determine the optimal PD-L1 threshold. Kaplan-Meier estimators and Cox proportional hazards regression models were also used. Results: On the basis of cumulative/dynamic receiver operating characteristic curves, we defined the cut-off score for PD-L1 expression as ≥25% of tumor cells positively stained. PD-L1 expression was a significant risk factor for nodal metastasis with crude and adjusted hazard ratios of 3.39 (1.71-6.65) and 6.54 (2.28-18.78), respectively. Limitations: This is a retrospective study limited to cSCC of the head and neck. Conclusion: These findings indicate that tumor PD-L1 expression predicts increased risk for nodal metastasis in patients with cSCC.

Year:

2017

Type of Publication:

Article

Journal:

Journal of the American Academy of Dermatology

Volume:

77

Number:

3

Pages:

527-533

Month:

September

DOI:

https://doi.org/10.1016/j.jaad.2017.05.047