Facultade de Fisioterapia

On the Combination of Omics Data for Prediction of Binary Outcomes

Rodríguez Girondo, Mar; Kakourou, Alexia; Salo, Perttu; Perola, Markus; Mesker, Wilma E.; Tollenaar, Rob A. E. M.; Houwing-Duistermaat, Jeanine; Mertens, Bart J. A.
Enrichment of predictive models with new biomolecular markers is an important task in high-dimensional omic applications. Increasingly, clinical studies include several sets of such omics markers available for each patient, measuring different levels of biological variation. As a result, one of the main challenges in predictive research is the integration of different sources of omic biomarkers for the prediction of health traits. We review several approaches for the combination of omic markers in the context of binary outcome prediction, all based on double cross-validation and regularized regression models. We evaluate their performance in terms of calibration and discrimination and we compare their performance with respect to single-omic source predictions. We illustrate the methods through the analysis of two real datasets. On the one hand, we consider the combination of two fractions of proteomic mass spectrometry for the calibration of a diagnostic rule for the detection of early stage breast cancer. On the other hand, we consider transcriptomics and metabolomics as predictors of obesity using data from the Dietary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome (DILGOM) study, a population-based cohort, from Finland.
Type of Publication:
Book Chapter
Prediction; Classification; Combination; Augmented prediction; Double cross validation; Regularized regression
Susmita Datta; Bart J. A. Mertens
Statistical Analysis of Proteomics, Metabolomics, and Lipidomics Data Using Mass Spectrometry
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